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GNRH1 - gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Entrez Gene Name: gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Entrez GeneID: Human(2796), Mouse(14714), Rat(25194)
Synonyms: GNRH, GNRH I, GNRH1, Gnrh2, GNRHA, GONADORELIN, GONADOTROPIN, Gonadotropin releasing hormone, GRH, hpg, LHRH, Lhrh1, LNRH, Rgnrhg1

Gene Summary

  • Rat (25194): involved in induction of ovulation; may inhibit anterior pituitary cell apoptosis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • Lh
  • Fsh
  • LHB
View all 148 in IPA
Regulated by:
  • N-methyl-D-aspartate
  • beta-estradiol
  • LEP
View all 174 in IPA
Binds:
  • GNRHR
  • POU2F1
  • MEF2C
View all 21 in IPA
Role in cell:
  • quantity
  • proliferation
  • desensitization
View all 26 in IPA
Disease:
  • endometriosis
  • precocious puberty
  • breast cancer
View all 20 in IPA

Biological Process

anti-apoptosis, cell-cell signaling, female pregnancy, multicellular organismal development, negative regulation of cell proliferation, ovulation, ovulation cycle, regulation of gene expression, response to corticosteroid stimulus, response to ethanol, response to steroid hormone stimulus, signal transduction

Cellular Components

extracellular region, extracellular space, soluble fraction

Literature References

  • 17823254Kowase T, Walsh HE, Darling DS, Shupnik MA. Estrogen Enhances Gonadotropin-Releasing Hormone-Stimulated Transcription of the Luteinizing Hormone Subunit Promoters via Altered Expression of Stimulatory and Suppressive Transcription Factors.Endocrinology 2007 Dec 01;148(12):6083-91
  • 17327421Maudsley S, Naor Z, Bonfil D, Davidson L, Karali D, Pawson AJ, Larder R, Pope C, Nelson N, Millar RP, Brown P. Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene.Mol Endocrinol 2007 May 01;21(5):1216-33
  • 17138645Naor Z, Jabbour HN, Naidich M, Pawson AJ, Morgan K, Battersby S, Millar MR, Brown P, Millar RP. Reciprocal Cross Talk between Gonadotropin-Releasing Hormone (GnRH) and Prostaglandin Receptors Regulates GnRH Receptor Expression and Differential Gonadotropin Secretion.Mol Endocrinol 2007 Feb 01;21(2):524-37
    • View 3060 categorized literature findings and their references in IPA

Molecular Functions

gonadotropin hormone-releasing hormone activity, hormone activity

Pathways

Protein Domains

intracellular loop, luteinizing hormone-releasing factor

Subcellular Locations

axon terminals, axons, cell body, cell surface, cellular membrane, cytoplasm, dendrites, extracellular space, membrane fraction, membrane processes, nerve ending, perikaryon

IPA Extras