SOAT1 - sterol O-acyltransferase 1
Entrez Gene Name: sterol O-acyltransferase 1
Entrez GeneID: Human(6646)
, Mouse(20652), Rat(81782)
, Mouse(20652), Rat(81782) Synonyms: 8430426K15RIK, ACACT, ACAT, ACAT-1, Acyl-Coenzyme A Cholesterol Acyltransferase, ald, AW550831, RP11-215I23.2, SOAT, SOAT1, STAT, Sterol O-acyltransferase 1
Gene Summary
- Human (6646): Acyl-coenzyme A:cholesterol acyltransferase (ACACT; EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988 [PubMed 3335499]).[supplied by OMIM]
- Rat (81782): catalyzes the conversion of free cholesterol and fatty acyl-CoA to cholesteryl esters; plays a role in cholesterol metabolism [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Regulates:
| Disease:
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Biological Process
cholesterol efflux, cholesterol esterification, cholesterol homeostasis, cholesterol metabolic process, cholesterol storage, foam cell differentiation, lipid metabolic process, positive regulation of amyloid precursor protein biosynthetic process, steroid metabolic process, very-low-density lipoprotein particle assembly
Cellular Components
endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome
Literature References
- 11239408Glass CK, Witztum JL. Atherosclerosis. the road ahead.Cell 2001 Feb 23;104(4):503-16
- 10846185Chang CC, Sakashita N, Ornvold K, Lee O, Chang ET, Dong R, Lin S, Lee CY, Strom SC, Kashyap R, Fung JJ, Farese RV, Patoiseau JF, Delhon A, Chang TY. Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine.J Biol Chem 2000 Sep 8;275(36):28083-92
- 10623671Sakashita N, Miyazaki A, Takeya M, Horiuchi S, Chang CC, Chang TY, Takahashi K. Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues.Am J Pathol 2000 Jan 1;156(1):227-36 View 257 categorized literature findings and their references in IPA
Molecular Functions
acyl-CoA binding, acyltransferase activity, cholesterol binding, cholesterol O-acyltransferase activity, ergosterol O-acyltransferase activity, lanosterol O-acyltransferase activity, phosphatidylcholine-sterol O-acyltransferase activity, sterol O-acyltransferase activity, transferase activity
Subcellular Locations
cellular membrane, cytoplasm, dendrites, endoplasmic reticulum, endoplasmic reticulum membrane, nuclear envelope, perinuclear region, pH resistant lipid raft fraction
