HTR3A - 5-hydroxytryptamine (serotonin) receptor 3A
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 3A
Entrez GeneID: Human(3359)
, Mouse(15561), Rat(79246)
, Mouse(15561), Rat(79246) Synonyms: 5-HT-3, 5-HT3A, 5-HT3R, 5HT3A RECEPTOR, HTR3, HTR3A
Gene Summary
- Human (3359): The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
- Rat (79246): receptor for 5-hydroxytryptamine (serotonin); functions as a ligand-gated ion channel [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Cellular Components
cell junction, integral to membrane, integral to plasma membrane, membrane, plasma membrane, postsynaptic membrane, synapse
Literature References
- 10681544Spier AD, Lummis SC. The role of tryptophan residues in the 5-Hydroxytryptamine(3) receptor ligand binding domain.J Biol Chem 2000 Feb 25;275(8):5620-5
- 10026168Yan D, Schulte MK, Bloom KE, White MM. Structural features of the ligand-binding domain of the serotonin 5HT3 receptor.J Biol Chem 1999 Feb 26;274(9):5537-41
- 9698312Bedford FK, Julius D, Ingraham HA. Neuronal expression of the 5HT3 serotonin receptor gene requires nuclear factor 1 complexes.J Neurosci 1998 Aug 15;18(16):6186-94 View 377 categorized literature findings and their references in IPA
Molecular Functions
extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, receptor activity, serotonin binding, serotonin receptor activity, serotonin-activated cation-selective channel activity
Protein Domains
extracellular ligand binding domain, ion channel, neurotransmitter-gated ion channel ligand binding domain, serotonin-activated cation-selective channel
Subcellular Locations
cell surface, cellular membrane, cytoplasm, membrane fraction, plasma membrane
