ACTR2 - ARP2 actin-related protein 2 homolog (yeast)
Entrez Gene Name: ARP2 actin-related protein 2 homolog (yeast)
Entrez GeneID: Human(10097)
, Mouse(66713), Rat(289820)
, Mouse(66713), Rat(289820) Synonyms: 4921510D23Rik, AA409782, Actin-like protein 2, ACTR2, ARP2, D6Ertd746e, MGC36604, MGC95085
Gene Summary
- Human (10097): The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Literature References
- 17220302Yoo Y, Wu X, Guan JL. A Novel Role of the Actin-nucleating Arp2/3 Complex in the Regulation of RNA Polymerase II-dependent Transcription.J Biol Chem 2007 Mar 09;282(10):7616-23
- 17353931Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. Large-scale mapping of human protein-protein interactions by mass spectrometry.Mol Syst Biol 2007 01 1;3:89
- 10746731Lewis KA, Gray PC, Blount AL, MacConell LA, Wiater E, Bilezikjian LM, Vale W. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling.Nature 2000 Mar 23;404(6776):411-4 View 299 categorized literature findings and their references in IPA
- Clathrin-mediated Endocytosis Signaling
- Integrin Signaling
- CD28 Signaling in T Helper Cells
- Cdc42 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Actin Cytoskeleton Signaling
- Regulation of Actin-based Motility by Rho
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- Axonal Guidance Signaling
