SLC6A1 - solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Entrez Gene Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Entrez GeneID: Human(6529)
, Mouse(232333), Rat(79212)
, Mouse(232333), Rat(79212) Synonyms: A730043E01, GABATHG, GABATR, Gabt, GABT1, GAT-1, SLC6A1, XT-1, Xtrp1
Gene Summary
- Rat (79212): transporter for the neurotransmitter gamma-aminobutyric acid (GABA) [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Biological Process
gamma-aminobutyric acid import, learning, negative regulation of synaptic transmission, GABAergic, neurotransmitter transport, protein homooligomerization, response to calcium ion, response to cocaine, response to estradiol stimulus, response to lead ion, response to organic cyclic substance, response to organic nitrogen, response to organic substance, response to purine, response to sucrose stimulus, response to toxin, synaptic transmission, transport
Cellular Components
axon, integral to membrane, integral to plasma membrane, membrane, membrane fraction, plasma membrane, synaptosome
Literature References
- 15073174Farhan H, Korkhov VM, Paulitschke V, Dorostkar MM, Scholze P, Kudlacek O, Freissmuth M, Sitte HH. Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1).J Biol Chem 2004 Jul 02;279(27):28553-63
- 9698305Beckman ML, Bernstein EM, Quick MW. Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A.J Neurosci 1998 Aug 15;18(16):6103-12
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78 View 140 categorized literature findings and their references in IPA
Molecular Functions
gamma-aminobutyric acid:sodium symporter activity, neurotransmitter:sodium symporter activity, protein binding, symporter activity
Subcellular Locations
apical membrane, axons, cell surface, cellular membrane, nerve ending, neurites, plasma membrane
