PRKCB - protein kinase C, beta
Entrez Gene Name: protein kinase C, beta
Entrez GeneID: Human(5579)
, Mouse(18751), Rat(25023)
, Mouse(18751), Rat(25023) Synonyms: A130082F03Rik, MGC41878, PKC BETA, PKC BETA 1, PKC Type II, PKC Type III, PKCB, PRKCB, PRKCB1, PRKCB2
Gene Summary
- Human (5579): Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
- Rat (25023): plays a role in hexosamine biosynthesis pathway induced transcriptional regulation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
calcium ion transport, cellular calcium ion homeostasis, intracellular signaling cascade, lipoprotein transport, positive regulation of odontogenesis of dentine-containing tooth, protein amino acid phosphorylation, regulation of dopamine secretion, regulation of growth, response to drug, response to ethanol, response to glucose stimulus, response to vitamin D
Cellular Components
centrosome, cytoplasm, cytosol, membrane, membrane fraction, nucleus, plasma membrane, soluble fraction
Literature References
- 10836144Sah VP, Seasholtz TM, Sagi SA, Brown JH. The role of Rho in G protein-coupled receptor signal transduction.Annu Rev Pharmacol Toxicol 2000;40:459-89
- 10358768Kurosaki T. Genetic analysis of B cell antigen receptor signaling.Annu Rev Immunol 1999 01 1;17:555-92
- 9858769Herdegen T, Leah JD. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.Brain Res Brain Res Rev 1998 Dec;28(3):370-490 View 4500 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, calcium channel regulator activity, calcium ion binding, diacylglycerol binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein kinase C activity, protein serine/threonine kinase activity, transferase activity, zinc ion binding
- Xenobiotic Metabolism Signaling
- Synaptic Long Term Potentiation
- Factors Promoting Cardiogenesis in Vertebrates
- Thrombopoietin Signaling
- HGF Signaling
- CCR5 Signaling in Macrophages
- Erythropoietin Signaling
- Synaptic Long Term Depression
- Calcium-induced T Lymphocyte Apoptosis
- CXCR4 Signaling
- Virus Entry via Endocytic Pathways
- VEGF Signaling
- B Cell Receptor Signaling
- Hepatic Cholestasis
- Fc Epsilon RI Signaling
- PPARα/RXRα Activation
- Cholecystokinin/Gastrin-mediated Signaling
- G-Protein Coupled Receptor Signaling
- Melatonin Signaling
- Natural Killer Cell Signaling
- IL-8 Signaling
- α-Adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CREB Signaling in Neurons
- Aldosterone Signaling in Epithelial Cells
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- PDGF Signaling
- Macropinocytosis Signaling
- G Beta Gamma Signaling
- p70S6K Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Type II Diabetes Mellitus Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- NF-κB Activation by Viruses
- Neuregulin Signaling
- 14-3-3-mediated Signaling
- Huntington's Disease Signaling
- VDR/RXR Activation
- Axonal Guidance Signaling
- GNRH Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Leukocyte Extravasation Signaling
- Thrombin Signaling
- Growth Hormone Signaling
- RAR Activation
- GM-CSF Signaling
- Corticotropin Releasing Hormone Signaling
- Mechanisms of Viral Exit from Host Cells
- mTOR Signaling
- Renin-Angiotensin Signaling
- IL-3 Signaling
- Androgen Signaling
- fMLP Signaling in Neutrophils
- Prolactin Signaling
- NRF2-mediated Oxidative Stress Response
- NF-κB Signaling
- Molecular Mechanisms of Cancer
- LPS-stimulated MAPK Signaling
- Glioma Signaling
- Chemokine Signaling
- IL-12 Signaling and Production in Macrophages
Protein Domains
C1 domain, C1A domain, C1B domain, C2 domain, calcium channel regulator, carboxy terminal domain, catalytic domain, hydrophobic domain, kinase, protein binding, Protein kinase, protein kinase C, protein serine/threonine kinase, pseudosubstrate domain, regulatory domain
Subcellular Locations
apical membrane, axons, cell periphery, cellular membrane, cytoplasm, cytoplasmic fraction, cytoskeleton, cytosol, cytosolic fraction, detergent-insoluble fractions, granules, growth cone, melanosomal membrane, membrane fraction, membrane surface, neurites, nuclear envelope, nucleus, perinuclear region, plasma membrane, soluble fraction, synaptosomes
