FGF18 - fibroblast growth factor 18
Entrez Gene Name: fibroblast growth factor 18
Entrez GeneID: Human(8817)
, Mouse(14172), Rat(29369)
, Mouse(14172), Rat(29369) Synonyms: D130055P09RIK, FGF18, ZFGF5
Gene Summary
- Human (8817): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq]
- Rat (29369): fibroblast growth factor; may be a secreted signalling molecule in the adult lung [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
anatomical structure morphogenesis, angiogenesis, cell-cell signaling, chondrocyte development, endochondral ossification, fibroblast growth factor receptor signaling pathway, intramembranous ossification, lung development, nervous system development, ossification, positive regulation of cell proliferation, positive regulation of vascular endothelial growth factor receptor signaling pathway, signal transduction
Literature References
- 11937494Ohbayashi N, Shibayama M, Kurotaki Y, Imanishi M, Fujimori T, Itoh N, Takada S. FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis.Genes Dev 2002 Apr 1;16(7):870-9
- 11937493Liu Z, Xu J, Colvin JS, Ornitz DM. Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18.Genes Dev 2002 Apr 1;16(7):859-69
- 11741978Shimoaka T, Ogasawara T, Yonamine A, Chikazu D, Kawano H, Nakamura K, Itoh N, Kawaguchi H. Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10.J Biol Chem 2002 Mar 1;277(9):7493-500 View 167 categorized literature findings and their references in IPA
