LAMA2 - laminin, alpha 2
Entrez Gene Name: laminin, alpha 2
Entrez GeneID: Human(3908)
, Mouse(16773), Rat(309368)
, Mouse(16773), Rat(309368) Synonyms: 5830440B04, Dy, KIAA4087, LAMA2, LAMININ ALPHA2, Laminin M, Laminin M chain, LAMM, mer, MEROSIN, mKIAA4087
Gene Summary
- Human (3908): Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
cell adhesion, extracellular matrix organization, muscle organ development, myelination in the peripheral nervous system, positive regulation of synaptic transmission, cholinergic, regulation of cell adhesion, regulation of cell migration, regulation of embryonic development
Cellular Components
basal lamina, basement membrane, dendritic spine, extracellular matrix, extracellular region, extracellular space, laminin-1 complex, proteinaceous extracellular matrix, sarcolemma
Literature References
- 9530493Kamiguchi H, Hlavin ML, Yamasaki M, Lemmon V. Adhesion molecules and inherited diseases of the human nervous system.Annu Rev Neurosci 1998;21:97-125
- 14681233Yuasa K, Fukumoto S, Kamasaki Y, Yamada A, Fukumoto E, Kanaoka K, Saito K, Harada H, Arikawa-Hirasawa E, Miyagoe-Suzuki Y, Takeda S, Okamoto K, Kato Y, Fujiwara T. Laminin alpha2 is essential for odontoblast differentiation regulating dentin sialoprotein expression.J Biol Chem 2004 Mar 12;279(11):10286-92
- 14734715Vivinus-Nebot M, Rousselle P, Breittmayer JP, Cenciarini C, Berrih-Aknin S, Spong S, Nokelainen P, Cottrez F, Marinkovich MP, Bernard A. Mature human thymocytes migrate on laminin-5 with activation of metalloproteinase-14 and cleavage of CD44.J Immunol 2004 02 1;172(3):1397-406 View 428 categorized literature findings and their references in IPA
Protein Domains
ERM homology domain, heparin binding domain, laminin B domain, laminin EGF-like domain, laminin G domain, Laminin-G repeat, MCP signaling domain, spectrin repeat, structural molecule, tail domain
Subcellular Locations
axon terminals, basal lamina, basement membrane, cell surface, extracellular space, neuromuscular junctions, perisynaptic region, plasma membrane, sarcolemma
