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LACTB - lactamase, beta
Entrez Gene Name: lactamase, beta
Synonyms: BETA LACTAMASE, FLJ14902, G24, LACT-1, LACTB, MRPL56

Gene Summary

  • Human (114294): This gene encodes a protein from the large 39S subunit of the mitochondrial ribosome (mitoribosome). The encoded protein has some sequence similarity to prokaryotic beta-lactamases but most of the residues that are responsible for the beta-lactamase activity are not conserved between the two proteins. [provided by RefSeq]

Cell Regulation

Regulates:
  • No Data Available
Regulated by:
  • Srp72
  • Dengue virus 2 Thailand/NGS-C/1944
View all 3 in IPA
Role in cell:
  • No Data Available
Disease:
  • No Data Available

Biological Process

No Data Available

Cellular Components

mitochondrion

Literature References

  • 15369676Gerald D, Berra E, Frapart YM, Chan DA, Giaccia AJ, Mansuy D, Pouysségur J, Yaniv M, Mechta-Grigoriou F. JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress.Cell 2004 Sep 17;118(6):781-94
  • 12629508Wells J, Yan PS, Cechvala M, Huang T, Farnham PJ. Identification of novel pRb binding sites using CpG microarrays suggests that E2F recruits pRb to specific genomic sites during S phase.Oncogene 2003 Mar 13;22(10):1445-60
  • 18698416van Sorge NM, Ebrahimi CM, McGillivray SM, Quach D, Sabet M, Guiney DG, Doran KS. Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis.PLoS ONE 2008 Jan 01;3(8):e2964
  • View 11 categorized literature findings and their references in IPA

Molecular Functions

hydrolase activity

Pathways

No Data Available

Protein Domains

No Data Available

Subcellular Locations

cytoplasm, microsome, mitochondria

IPA Extras

View additional information available in IPA's curated and annotated database: