GABRA3 - gamma-aminobutyric acid (GABA) A receptor, alpha 3
Entrez Gene Name: gamma-aminobutyric acid (GABA) A receptor, alpha 3
Entrez GeneID: Human(2556)
, Mouse(14396), Rat(24947)
, Mouse(14396), Rat(24947) Synonyms: GABA A RECEPTOR ALPHA-3, GABRA3, MGC33793
Gene Summary
- Human (2556): GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq]
- Rat (24947): may mediate inhibitory GABA responses; may play a role in synaptic transmission in the visual cortex [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Regulates:
| Role in cell:
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Biological Process
chloride transport, gamma-aminobutyric acid signaling pathway, ion transport, synaptic transmission, transport
Cellular Components
cell junction, cytoplasm, cytoskeleton, integral to membrane, integral to plasma membrane, membrane, plasma membrane, postsynaptic membrane, synapse
Literature References
- 16284244Yee BK, Keist R, von Boehmer L, Studer R, Benke D, Hagenbuch N, Dong Y, Malenka RC, Fritschy JM, Bluethmann H, Feldon J, Möhler H, Rudolph U. A schizophrenia-related sensorimotor deficit links {alpha}3-containing GABAA receptors to a dopamine hyperfunction.Proc Natl Acad Sci U S A 2005 Nov 22;102(47):17154-9
- 17630284Liu XB, Coble J, van Luijtelaar G, Jones EG. Reticular nucleus-specific changes in {alpha}3 subunit protein at GABA synapses in genetically epilepsy-prone rats.Proc Natl Acad Sci U S A 2007 Jul 24;104(30):12512-7
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363 View 256 categorized literature findings and their references in IPA
Molecular Functions
benzodiazepine receptor activity, chloride channel activity, chloride ion binding, extracellular ligand-gated ion channel activity, GABA-A receptor activity, ion channel activity, neurotransmitter receptor activity, protein binding, receptor activity
Protein Domains
benzodiazepine receptor, extracellular ligand binding domain, GABA-A receptor, intracellular domain, ion channel, neurotransmitter-gated ion channel ligand binding domain, protein binding
Subcellular Locations
apical processes, cellular membrane, membrane fraction, plasma membrane, postsynaptic density, presynaptic membrane, synapse, vitreal membranes
