NFATC2 - nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Entrez Gene Name: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Entrez GeneID: Human(4773)
, Mouse(18019), Rat(311658)
, Mouse(18019), Rat(311658) Synonyms: AI607462, NF-ATP, NFAT1, NFAT1-D, NFATC2
Gene Summary
- Human (4773): This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cytokine production, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, regulation of transcription, DNA-dependent, transcription
Literature References
- 15184502Zaichuk TA, Shroff EH, Emmanuel R, Filleur S, Nelius T, Volpert OV. Nuclear factor of activated T cells balances angiogenesis activation and inhibition.J Exp Med 2004 Jun 07;199(11):1513-22
- 12086671Macián F, García-Cózar F, Im SH, Horton HF, Byrne MC, Rao A. Transcriptional mechanisms underlying lymphocyte tolerance.Cell 2002 Jun 14;109(6):719-31
- 11956291Rengarajan J, Mowen KA, McBride KD, Smith ED, Singh H, Glimcher LH. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression.J Exp Med 2002 04 15;195(8):1003-12 View 1981 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, protein binding, sequence-specific DNA binding, transcription activator activity, transcription factor activity
- Glucocorticoid Receptor Signaling
- B Cell Activating Factor Signaling
- Role of NFAT in Regulation of the Immune Response
- Axonal Guidance Signaling
- April Mediated Signaling
- iCOS-iCOSL Signaling in T Helper Cells
- B Cell Receptor Signaling
- CD28 Signaling in T Helper Cells
- Systemic Lupus Erythematosus Signaling
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- IL-4 Signaling
- fMLP Signaling in Neutrophils
- T Cell Receptor Signaling
Protein Domains
DNA binding, DNA binding domain, IPT/TIG domain, nuclear localization sequence, protein binding, Rel homology domain, SP repeat domain, transcription activation domain, transcription factor, transcription regulator, transcriptional activator
