PLG - plasminogen
Entrez Gene Name: plasminogen
Entrez GeneID: Human(5340)
, Mouse(18815), Rat(85253)
, Mouse(18815), Rat(85253) Synonyms: Ab1-346, AI649309, DKFZp779M0222, GLU PLASMINOGEN, GLU-PG, LPA, Pg, PG2, PLASMINOGEN, PLG, Scdp
Gene Summary
- Human (5340): Plasminogen (PLG) is a circulating zymogen that is converted to the active enzyme plasmin by cleavage of the peptide bond between arg560 and val561, which is mediated by urokinase (PLAU; MIM 191840) and tissue plasminogen activator (PLAT; MIM 173370). The main function of plasmin is to dissolve fibrin (see, e.g., FGA, MIM 134820) clots. Plasmin, like trypsin, belongs to the family of serine proteinases (Miyata et al., 1982 [PubMed 6216475]; Forsgren et al., 1987 [PubMed 3030813]).[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, blood coagulation, fibrinolysis, induction of apoptosis, muscle maintenance, myoblast differentiation, negative regulation of angiogenesis, negative regulation of blood vessel endothelial cell migration, negative regulation of cell proliferation, negative regulation of fibrinolysis, positive regulation of fibrinolysis, proteolysis, proteolysis involved in cellular protein catabolic process, tissue regeneration, tissue remodeling
Literature References
- 11687497Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior.Annu Rev Cell Dev Biol 2001;17:463-516
- 17656680Horowitz JC, Rogers DS, Simon RH, Sisson TH, Thannickal VJ. Plasminogen activation induced pericellular fibronectin proteolysis promotes fibroblast apoptosis.Am J Respir Cell Mol Biol 2008 Jan 01;38(1):78-87
- 17690254Das R, Burke T, Plow EF. Histone H2B as a functionally important plasminogen receptor on macrophages.Blood 2007 Nov 15;110(10):3763-72 View 2226 categorized literature findings and their references in IPA
Molecular Functions
apolipoprotein binding, calcium ion binding, endopeptidase activity, hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity
Protein Domains
catalytic domain, endopeptidase, hormone, kringle domain, kringle V, PAN domain, peptidase, Plasmin, Serine endopeptidase
Subcellular Locations
cell surface, extracellular space, membrane fraction, plasma, plasma membrane, specific granules
