CYP3A4 - cytochrome P450, family 3, subfamily A, polypeptide 4
Entrez Gene Name: cytochrome P450, family 3, subfamily A, polypeptide 4
Entrez GeneID: Human(1576)
, Mouse(13112), Rat(25642)
, Mouse(13112), Rat(25642) Synonyms: AI256190, cDEX, CP33, CP34, CYP, CYP3A, CYP3A1, Cyp3a11, Cyp3a16, Cyp3a2, CYP3A23, Cyp3a23/3a1, CYP3A3, CYP3A4, CYP3A41, Cyp3a41a, Cyp3a44, CYTOCHROME P450 3A3, HLP, IIIAm1, MGC108545, MGC108757, MGC126680, MGC130513, NF-25, P-450ut-a, p450 3A4, P450C3, P450PCN1, Pcn, RL33
Gene Summary
- Human (1576): This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq]
- Rat (25642): steroid-inducible member of p450 subfamily 3A; induced by pregnenolone 16 alpha-carbonitrile, dexamethasone (DEX), phenobarbital (PB) and triacetyloleandomycin [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
aging, drug metabolic process, lipid metabolic process, oxidation reduction, response to cadmium ion, response to drug, response to glucocorticoid stimulus, response to metal ion, response to nutrient, steroid metabolic process, vitamin D metabolic process
Cellular Components
cell surface, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome
Literature References
- 11264468Lin JH, Lu AY. Interindividual variability in inhibition and induction of cytochrome P450 enzymes.Annu Rev Pharmacol Toxicol 2001;41:535-67
- 10935643Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, Neuschwander-Tetri BA, Brunt EM, Guzelian PS, Evans RM. Humanized xenobiotic response in mice expressing nuclear receptor SXR.Nature 2000 Jul 27;406(6794):435-9
- 17636047Masuyama H, Nakatsukasa H, Takamoto N, Hiramatsu Y. Down-regulation of pregnane x receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells.Mol Pharmacol 2007 Oct 01;72(4):1045-53 View 2552 categorized literature findings and their references in IPA
Molecular Functions
albendazole monooxygenase activity, aromatase activity, demethylase activity, electron carrier activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, oxygen binding, quinine 3-monooxygenase activity, steroid binding, taurochenodeoxycholate 6alpha-hydroxylase activity, testosterone 6-beta-hydroxylase activity, vitamin D3 25-hydroxylase activity
Protein Domains
Cholestanetetraol 26-dehydrogenase, enzyme, monooxygenase, oxygen binding, Quinine 3-monooxygenase, testosterone 6-beta-hydroxylase, Unspecific monooxygenase
Subcellular Locations
cell surface, cellular membrane, cytoplasm, endoplasmic reticulum membrane, Golgi membranes, microsomal fraction, microsome
