ADRB1 - adrenergic, beta-1-, receptor
Entrez Gene Name: adrenergic, beta-1-, receptor
Entrez GeneID: Human(153)
, Mouse(11554), Rat(24925)
, Mouse(11554), Rat(24925) Synonyms: ADRB1, ADRB1R, Adrenergic Receptor Beta 1, B1AR, BETA-AR, BETA1 ADRENERGIC RECEPTOR, BETA1-ADRENORECEPTOR, BETA1AR, RATB1AR, RHR
Gene Summary
- Human (153): The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq]
- Rat (24925): binds beta-adrenergic receptor agonists isoproterenol, norepinephrine, and epinephrine; mediates adenylylcyclase induction; involved in regulation of calcium current [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of adenylate cyclase activity by G-protein signaling pathway, brown fat cell differentiation, diet induced thermogenesis, fear response, G-protein coupled receptor protein signaling pathway, heat generation, negative regulation of multicellular organism growth, positive regulation of heart rate by epinephrine-norepinephrine, positive regulation of the force of heart contraction by epinephrine-norepinephrine, regulation of synaptic plasticity, response to cold, signal transduction, vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
Cellular Components
integral to membrane, integral to plasma membrane, membrane, membrane fraction, microsome, plasma membrane
Literature References
- 19246813Yoshikawa T, Baba A, Nagatomo Y. Autoimmune mechanisms underlying dilated cardiomyopathy.Circ J 2009 Apr 01;73(4):602-7
- 17620508Jane-wit D, Altuntas CZ, Johnson JM, Yong S, Wickley PJ, Clark P, Wang Q, Popović ZB, Penn MS, Damron DS, Perez DM, Tuohy VK. Beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis.Circulation 2007 Jul 24;116(4):399-410
- 17515456Kim SM, Chen L, Faulhaber-Walter R, Oppermann M, Huang Y, Mizel D, Briggs JP, Schnermann J. Regulation of renin secretion and expression in mice deficient in beta1- and beta2-adrenergic receptors.Hypertension 2007 Jul 01;50(1):103-9 View 1251 categorized literature findings and their references in IPA
Molecular Functions
adrenoceptor activity, beta1-adrenergic receptor activity, dopamine binding, drug binding, epinephrine binding, G-protein coupled receptor activity, norepinephrine binding, PDZ domain binding, protein binding, receptor activity, signal transducer activity
Protein Domains
beta1-adrenergic receptor, carboxy terminal domain, class 1 pdz domain, drug binding, extracellular loop, G-protein coupled receptor, PDZ-domain binding, proline rich domain, protein binding, transmembrane domain
Subcellular Locations
caveolae, cell body, cell surface, cellular membrane, cytoplasm, lysosome, membrane fraction, membrane rafts, plasma membrane
