FGF7 - fibroblast growth factor 7 (keratinocyte growth factor)
Entrez Gene Name: fibroblast growth factor 7 (keratinocyte growth factor)
Entrez GeneID: Human(2252)
, Mouse(14178), Rat(29348)
, Mouse(14178), Rat(29348) Synonyms: FGF7, HBGF-7, keratinocyte growth factor, KGF
Gene Summary
- Human (2252): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq]
- Rat (29348): mediates glucocorticoid induction of fetal lung maturation; involved in regulation of surfactant synthesis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell proliferation, epidermis development, fibroblast growth factor receptor signaling pathway, hair follicle morphogenesis, lung development, ovarian follicle development, phosphatidylcholine biosynthetic process, phospholipid biosynthetic process, positive regulation of cell proliferation, positive regulation of epithelial cell proliferation, response to wounding, signal transduction, surfactant homeostasis, wound healing
Literature References
- 7688944Fantl WJ, Johnson DE, Williams LT. Signalling by receptor tyrosine kinases.Annu Rev Biochem 1993;62:453-81
- 17138819Min D, Panoskaltsis-Mortari A, Kuro-O M, Holländer GA, Blazar BR, Weinberg KI. Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging.Blood 2007 Mar 15;109(6):2529-37
- 16373332McDowell LM, Frazier BA, Studelska DR, Giljum K, Chen J, Liu J, Yu K, Ornitz DM, Zhang L. Inhibition or Activation of Apert Syndrome FGFR2 (S252W) Signaling by Specific Glycosaminoglycans.J Biol Chem 2006 Mar 17;281(11):6924-30 View 821 categorized literature findings and their references in IPA
Molecular Functions
growth factor activity, heparin binding, type 2 fibroblast growth factor receptor binding
Protein Domains
growth factor, heparin binding, loop domain, type 2 fibroblast growth factor receptor binding
