LAG3 - lymphocyte-activation gene 3
Entrez Gene Name: lymphocyte-activation gene 3
Entrez GeneID: Human(3902)
, Mouse(16768), Rat(297596)
, Mouse(16768), Rat(297596) Synonyms: CD223, LAG3, Ly66, MGC108901
Gene Summary
- Human (3902): Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq]
- Rat (297596): mouse homolog regulates the proliferation of activated T-cells [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Regulates:
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Biological Process
cell surface receptor linked signal transduction, negative regulation of interleukin-2 biosynthetic process, negative regulation of T cell activation, positive regulation of natural killer cell mediated cytotoxicity
Literature References
- 11592063Iouzalen N, Andreae S, Hannier S, Triebel F. LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway.Eur J Immunol 2001 Oct 1;31(10):2885-91
- 9159144Huard B, Mastrangeli R, Prigent P, Bruniquel D, Donini S, El-Tayar N, Maigret B, Dreano M, Triebel F. Characterization of the major histocompatibility complex class II binding site on LAG-3 protein.Proc Natl Acad Sci U S A 1997 May 27;94(11):5744-9
- 12421911Workman CJ, Dugger KJ, Vignali DA. Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3.J Immunol 2002 11 15;169(10):5392-5 View 120 categorized literature findings and their references in IPA
Protein Domains
antigen binding, Glu-Pro repeat domain, immunoglobulin domain, intracellular domain, MHC class II protein binding, transmembrane receptor
