GRIN1 - glutamate receptor, ionotropic, N-methyl D-aspartate 1
Entrez Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 1
Entrez GeneID: Human(2902)
, Mouse(14810), Rat(24408)
, Mouse(14810), Rat(24408) Synonyms: Glur zeta1, GluRdelta1, GRIN1, N-METHYL-D-ASPARTATE R1 GLUTAMATE RECEPTOR, Nmda nr1, NMDA Receptor, NMDA1, NMDAR, Nmdar nr1, NMDAR1, NR1
Gene Summary
- Human (2902): The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq]
- Rat (24408): subunit of NMDA-preferring ionotropic glutamate receptors; may play a role in long term potentiation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
adult locomotory behavior, associative learning, calcium ion homeostasis, calcium ion transport, cation transport, cellular calcium ion homeostasis, cerebral cortex development, conditioned taste aversion, ion transport, ionotropic glutamate receptor signaling pathway, learning, learning or memory, long-term memory, male mating behavior, memory, negative regulation of neuron apoptosis, neuromuscular process, olfactory learning, pons maturation, positive regulation of apoptosis, positive regulation of transcription from RNA polymerase II promoter, prepulse inhibition, regulation of axonogenesis, regulation of cell communication, regulation of dendrite morphogenesis, regulation of excitatory postsynaptic membrane potential, regulation of long-term neuronal synaptic plasticity, regulation of membrane potential, regulation of neuron apoptosis, regulation of neuronal synaptic plasticity, regulation of respiratory gaseous exchange, regulation of synaptic plasticity, regulation of synaptogenesis, respiratory gaseous exchange, response to amphetamine, response to ethanol, response to morphine, rhythmic process, sensory perception of pain, social behavior, startle response, suckling behavior, synaptic transmission, synaptic transmission, glutamatergic, transport, visual learning
Cellular Components
cell junction, cytoplasm, dendrite, dendritic spine, growth cone, integral to membrane, integral to plasma membrane, membrane, membrane fraction, N-methyl-D-aspartate selective glutamate receptor complex, plasma membrane, postsynaptic density, postsynaptic membrane, synapse, synaptic cleft, synaptic vesicle, synaptosome
Literature References
- 17556551McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, Tonegawa S. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network.Science 2007 07 6;317(5834):94-9
- 10774735Fayyazuddin A, Villarroel A, Le Goff A, Lerma J, Neyton J. Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors.Neuron 2000 Mar 1;25(3):683-94
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363 View 2287 categorized literature findings and their references in IPA
Molecular Functions
calcium channel activity, calcium ion binding, calmodulin binding, cation channel activity, extracellular-glutamate-gated ion channel activity, glutamate binding, glutamate receptor binding, glycine binding, ion channel activity, ionotropic glutamate receptor activity, magnesium ion binding, N-methyl-D-aspartate selective glutamate receptor activity, neurotransmitter binding, protein binding, receptor activity, receptor binding, voltage-gated cation channel activity
Protein Domains
calcium channel, calcium ion binding, calmodulin binding, calmodulin binding domain, carboxy terminal domain, cation channel, extracellular ligand binding domain, glutamate binding, glycine binding, ion channel, ionotropic glutamate receptor, N-methyl-D-aspartate selective glutamate receptor, neurotransmitter binding, protein binding, receptor binding
Subcellular Locations
axospinous synapses, cell body, cell periphery, cell surface, cellular membrane, coarse fibers, cytoplasm, cytosol, dendrites, dendritic shafts, dendritic spines, detergent-insoluble fractions, endoplasmic reticulum, excitatory synapses, intracellular space, membrane fraction, membrane processes, nerve ending, neurites, perinuclear region, plasma membrane, postsynaptic density, postsynaptic density (PSD) fractions, somatodendritic region, synapse, synaptic plasma membrane fractions, synaptic spine, synaptic vesicle fractions, synaptosomal fractions, synaptosomal membrane fractions, synaptosomes, vesicle fraction
