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CHRNB3 - cholinergic receptor, nicotinic, beta 3
Entrez Gene Name: cholinergic receptor, nicotinic, beta 3
Entrez GeneID: Human(1142), Mouse(108043), Rat(171131)
Synonyms: 5730417K16Rik, Acrb3, BETA3 NACHR, CHRNB3, nAChR beta3

Gene Summary

  • Rat (171131): nicotinic acetylcholine receptor subunit beta 3 [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • FYN
  • catecholamine
  • dopamine
View all 6 in IPA
Regulated by:
  • AGRN
  • staurosporine
  • herbimycin
View all 29 in IPA
Binds:
  • acetylcholine
  • nicotine
  • pipecuronium
View all 26 in IPA
Role in cell:
  • depolarization
  • damage
  • long term depression in
View all 5 in IPA
Disease:
  • Alzheimer's disease
  • lung cancer
  • experimental autoimmune myasthenia gravis
View all 30 in IPA

Biological Process

ion transport, protein heterooligomerization, signal transduction, synaptic transmission, cholinergic, transport

Cellular Components

cell junction, integral to membrane, membrane, membrane fraction, nicotinic acetylcholine-gated receptor-channel complex, plasma membrane, postsynaptic membrane, synapse, synaptosome

Literature References

  • 15213299Moretti M, Vailati S, Zoli M, Lippi G, Riganti L, Longhi R, Viegi A, Clementi F, Gotti C. Nicotinic Acetylcholine Receptor Subtypes Expression during Rat Retina Development and Their Regulation by Visual Experience.Mol Pharmacol 2004 Jul 01;66(1):85-96
  • 9442882Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases.Annu Rev Cell Dev Biol 1997;13:513-609
  • 12069578Molles BE, Tsigelny I, Nguyen PD, Gao SX, Sine SM, Taylor P. Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface site.Biochemistry 2002 Jun 25;41(25):7895-906
    • View 215 categorized literature findings and their references in IPA

Molecular Functions

acetylcholine binding, channel activity, drug binding, extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, nicotinic acetylcholine-activated cation-selective channel activity, receptor activity

Pathways

Protein Domains

channel/pore class transporter, extracellular ligand binding domain, extracellular ligand-gated ion channel, GABA-A receptor, ion channel, neurotransmitter-gated ion channel ligand binding domain, nicotinic acetylcholine-activated cation-selective channel, transmembrane receptor

Subcellular Locations

cellular membrane, plasma membrane, synaptosomes

IPA Extras