GAST - gastrin
Entrez Gene Name: gastrin
Entrez GeneID: Human(2520)
, Mouse(14459), Rat(25320)
, Mouse(14459), Rat(25320) Synonyms: G-GLY, GAS, GAST, GASTRIN, Gastrin-17, PPG34
Gene Summary
- Human (2520): Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq]
- Rat (25320): increases gastric mucosal integrity through induction of COX-2 expression [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Literature References
- 17671195Rengifo-Cam W, Umar S, Sarkar S, Singh P. Antiapoptotic Effects of Progastrin on Pancreatic Cancer Cells Are Mediated by Sustained Activation of Nuclear Factor-{kappa}B.Cancer Res 2007 Aug 01;67(15):7266-74
- 15805277Ferrand A, Bertrand C, Portolan G, Cui G, Carlson J, Pradayrol L, Fourmy D, Dufresne M, Wang TC, Seva C. Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors.Cancer Res 2005 Apr 01;65(7):2770-7
- 15292219Lei S, Dubeykovskiy A, Chakladar A, Wojtukiewicz L, Wang TC. The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways.J Biol Chem 2004 Oct 08;279(41):42492-502 View 658 categorized literature findings and their references in IPA
