CNR1 - cannabinoid receptor 1 (brain)
Entrez Gene Name: cannabinoid receptor 1 (brain)
Entrez GeneID: Human(1268)
, Mouse(12801), Rat(25248)
, Mouse(12801), Rat(25248) Synonyms: CANN6, Cannabinoid cb1 receptor, Cannabinoid Receptor, CB-R, CB1, CB1 RECEPTORS, CB1A, CB1K5, CB1R, CNR, CNR1, CNR1 isoform 1, SKR6R
Gene Summary
- Human (1268): This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq]
- Rat (25248): G-protein coupled receptor for psychoactive cannabinoids; may mediate inhibition of NO production and participate in retrograde signaling by endocannabinoids [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
behavior, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, signal transduction
Literature References
- 16402900Mackie K. Cannabinoid receptors as therapeutic targets.Annu Rev Pharmacol Toxicol 2006 Jan 01;46:101-22
- 10817752Yagi T, Takeichi M. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.Genes Dev 2000 May 15;14(10):1169-80
- 18676872Wang D, Wang H, Ning W, Backlund MG, Dey SK, Dubois RN. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth.Cancer Res 2008 Aug 01;68(15):6468-76 View 1529 categorized literature findings and their references in IPA
Molecular Functions
cannabinoid receptor activity, drug binding, G-protein coupled receptor activity, receptor activity, signal transducer activity
Protein Domains
cannabinoid receptor, drug binding, extracellular loop, G-protein coupled receptor, tail domain, transmembrane domain
Subcellular Locations
axon terminals, axons, cell body, cell surface, cellular membrane, cytoplasm, dendrites, detergent-soluble membrane fractions, endoplasmic reticulum, endosomes, Golgi apparatus, granules, growth cone, inner membrane, intracellular space, membrane fraction, multivesicular bodies, nerve ending, neurites, nucleus, perinuclear region, plasma membrane, plasma membrane fraction, postsynaptic density, presynaptic terminals, rough endoplasmatic reticulum, synapse, synaptic clefts, synaptosomal membrane fractions, synaptosomes, vesicles
