CUL4B - cullin 4B
Entrez Gene Name: cullin 4B
Entrez GeneID: Human(8450)
, Mouse(72584), Rat(302502)
, Mouse(72584), Rat(302502) Synonyms: 2700050M05Rik, AA409770, CUL4B, CUL4B isoform 1, DKFZp686F1470, KIAA0695, mKIAA0695, MRXHF2, MRXSC, RGD1564494, SFM2
Gene Summary
- Human (8450): This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
|
Biological Process
cell cycle, DNA repair, response to DNA damage stimulus, ubiquitin-dependent protein catabolic process
Literature References
- 17041588Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.Nat Cell Biol 2006 11 1;8(11):1277-83
- 10597293Hori T, Osaka F, Chiba T, Miyamoto C, Okabayashi K, Shimbara N, Kato S, Tanaka K. Covalent modification of all members of human cullin family proteins by NEDD8.Oncogene 1999 Nov 18;18(48):6829-34
- 17392787Ohtake F, Baba A, Takada I, Okada M, Iwasaki K, Miki H, Takahashi S, Kouzmenko A, Nohara K, Chiba T, Fujii-Kuriyama Y, Kato S. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.Nature 2007 03 29;446(7135):562-6 View 84 categorized literature findings and their references in IPA
