CNR2 - cannabinoid receptor 2 (macrophage)
Entrez Gene Name: cannabinoid receptor 2 (macrophage)
Entrez GeneID: Human(1269)
, Mouse(12802), Rat(57302)
, Mouse(12802), Rat(57302) Synonyms: Cannabinoid Receptor2, CB2, CB2 RECEPTOR, CB2-R, CNR2, CX5
Gene Summary
- Human (1269): The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq]
- Rat (57302): G-protein-coupled transmembrane receptor; pertussis toxin-sensitive modulator of adenylate cyclase activity [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
behavior, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, immune response, inflammatory response, signal transduction
Cellular Components
cell projection, dendrite, integral to membrane, integral to plasma membrane, membrane, perikaryon, plasma membrane
Literature References
- 16402900Mackie K. Cannabinoid receptors as therapeutic targets.Annu Rev Pharmacol Toxicol 2006 Jan 01;46:101-22
- 10817752Yagi T, Takeichi M. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.Genes Dev 2000 May 15;14(10):1169-80
- 17329257DeMorrow S, Glaser S, Francis H, Venter J, Vaculin B, Vaculin S, Alpini G. Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts.J Biol Chem 2007 Apr 27;282(17):13098-113 View 720 categorized literature findings and their references in IPA
Molecular Functions
cannabinoid receptor activity, G-protein coupled receptor activity, receptor activity, signal transducer activity
Protein Domains
cannabinoid receptor, carboxy terminal domain, extracellular loop, G-protein coupled receptor, transmembrane domain
Subcellular Locations
cell surface, cellular membrane, cytoplasm, membrane fraction, perinuclear region, plasma membrane
