EDNRA - endothelin receptor type A
Entrez Gene Name: endothelin receptor type A
Entrez GeneID: Human(1909)
, Mouse(13617), Rat(24326)
, Mouse(13617), Rat(24326) Synonyms: EDNRA, ENDOR, ENDOTHELIN RECEPTOR TYPE A, ET-AR, Et1 receptor, ETA, ETA RECEPTOR, ETRA, Gpcr10, RATENDOR
Gene Summary
- Rat (24326): binds endothelin 1 and induces an increase in intracellular calcium [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of adenylate cyclase activity, activation of phospholipase C activity, activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, artery smooth muscle contraction, cell proliferation, elevation of cytosolic calcium ion concentration, elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating), G-protein coupled receptor protein signaling pathway, glucose transport, heart development, in utero embryonic development, negative regulation of cAMP biosynthetic process, neural crest cell development, patterning of blood vessels, positive regulation of calcium ion transport, positive regulation of inflammatory response, positive regulation of protein amino acid phosphorylation, positive regulation of release of sequestered calcium ion into cytosol, regulation of blood pressure, regulation of epithelial cell proliferation, respiratory gaseous exchange, response to hypoxia, response to morphine, signal transduction, smooth muscle contraction, vasoconstriction
Cellular Components
integral to membrane, integral to plasma membrane, membrane, nuclear membrane, plasma membrane, T-tubule
Literature References
- 12743035Gschwind A, Hart S, Fischer OM, Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.EMBO J 2003 May 15;22(10):2411-2421
- 17332141Chung KY, Walker JW. Interaction and Inhibitory Cross-Talk between Endothelin and ErbB Receptors in the Adult Heart.Mol Pharmacol 2007 Jun 01;71(6):1494-502
- 10836144Sah VP, Seasholtz TM, Sagi SA, Brown JH. The role of Rho in G protein-coupled receptor signal transduction.Annu Rev Pharmacol Toxicol 2000;40:459-89 View 571 categorized literature findings and their references in IPA
Molecular Functions
endothelin receptor activity, endothelin-A receptor activity, G-protein coupled receptor activity, phosphoinositide phospholipase C activity, protein binding, protein tyrosine kinase activity, receptor activity, signal transducer activity
Protein Domains
carboxy terminal domain, endothelin receptor, endothelin-A receptor, G-protein coupled receptor, protein binding, transmembrane receptor
Subcellular Locations
cell body, cell surface, cellular membrane, cytoplasm, membrane fraction, plasma membrane, transverse tubules
