CHRNA3 - cholinergic receptor, nicotinic, alpha 3
Entrez Gene Name: cholinergic receptor, nicotinic, alpha 3
Entrez GeneID: Human(1136)
, Mouse(110834), Rat(25101)
, Mouse(110834), Rat(25101) Synonyms: (a)3, A730007P14Rik, Acra-3, ALPHA 3 NICOTINIC RECEPTOR SUBUNIT, CHRNA3, LNCR2, MGC104879, nAChR alpha3, NACHR ALPHA3 SUBUNIT, PAOD2
Gene Summary
- Rat (25101): subunit of nicotinic acetylcholine receptor that is specific to the brain and peripheral nervous system [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of transmembrane receptor protein tyrosine kinase activity, behavioral response to nicotine, heart development, ion transport, locomotory behavior, nervous system development, protein heterooligomerization, regulation of acetylcholine secretion, regulation of dendrite morphogenesis, regulation of excitatory postsynaptic membrane potential, regulation of membrane potential, regulation of muscle contraction, regulation of smooth muscle contraction, response to drug, response to inorganic substance, response to nicotine, signal transduction, synaptic transmission involved in micturition, synaptic transmission, cholinergic, transport
Cellular Components
cell junction, cell soma, dendrite, integral to membrane, membrane, membrane fraction, nicotinic acetylcholine-gated receptor-channel complex, plasma membrane, postsynaptic density, postsynaptic membrane, synapse
Literature References
- 17344216Benfante R, Flora A, Di Lascio S, Cargnin F, Longhi R, Colombo S, Clementi F, Fornasari D. Transcription factor PHOX2A regulates the human alpha3 nicotinic receptor subunit gene promoter.J Biol Chem 2007 May 04;282(18):13290-302
- 16738207Broad LM, Zwart R, Pearson KH, Lee M, Wallace L, McPhie GI, Emkey R, Hollinshead SP, Dell CP, Baker SR, Sher E. Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.J Pharmacol Exp Ther 2006 Sep 01;318(3):1108-17
- 15681842Arredondo J, Chernyavsky AI, Marubio LM, Beaudet AL, Jolkovsky DL, Pinkerton KE, Grando SA. Receptor-Mediated Tobacco Toxicity: Regulation of Gene Expression through {alpha}3{beta}2 Nicotinic Receptor in Oral Epithelial Cells.Am J Pathol 2005 Feb 01;166(2):597-613 View 619 categorized literature findings and their references in IPA
Molecular Functions
acetylcholine binding, acetylcholine receptor activity, drug binding, extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, nicotinic acetylcholine-activated cation-selective channel activity, receptor activity
Protein Domains
acetylcholine binding, acetylcholine receptor, extracellular ligand binding domain, neurotransmitter-gated ion channel ligand binding domain, nicotinic acetylcholine-activated cation-selective channel, transmembrane receptor
