E2F2 - E2F transcription factor 2
Entrez Gene Name: E2F transcription factor 2
Entrez GeneID: Human(1870)
, Mouse(242705)
, Mouse(242705) Synonyms: 9230110J10, E130207A07, E2F2
Gene Summary
- Human (1870): The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
apoptosis, cell cycle, regulation of cell cycle, regulation of transcription, regulation of transcription, DNA-dependent, transcription, transcription initiation from RNA polymerase II promoter
Literature References
- 12411495Schlisio S, Halperin T, Vidal M, Nevins JR. Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.EMBO J 2002 Nov 1;21(21):5775-5786
- 11799066Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.Genes Dev 2002 Jan 15;16(2):235-44
- 11719808Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G. The E2F1-3 transcription factors are essential for cellular proliferation.Nature 2001 Nov 22;414(6862):457-62 View 1205 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, protein binding, RNA polymerase II transcription factor activity, transcription factor activity
Protein Domains
protein binding, RNA polymerase II transcription factor, transcription activation domain, transcription factor, transcription regulator
