EDN1 - endothelin 1
Entrez Gene Name: endothelin 1
Entrez GeneID: Human(1906)
, Mouse(13614), Rat(24323)
, Mouse(13614), Rat(24323) Synonyms: BIG ENDOTHELIN1, EDN1, ENDOTHELIN-1, ET-1, HDLCQ7, preproET
Gene Summary
- Rat (24323): activates ERK1/2 mediated signaling; may play a role in regulation of cardiac contractile force [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway, activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, artery smooth muscle contraction, blood vessel morphogenesis, body fluid secretion, calcium-mediated signaling, cartilage development, cell-cell signaling, diuresis, dorsal/ventral pattern formation, elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating), G-protein coupled receptor protein signaling pathway, glucose transport, heart development, in utero embryonic development, inositol phosphate-mediated signaling, leukocyte activation, membrane depolarization, middle ear morphogenesis, natriuresis, negative regulation of blood coagulation, negative regulation of cAMP biosynthetic process, negative regulation of hormone secretion, negative regulation of nitric-oxide synthase biosynthetic process, neural crest cell development, neutrophil chemotaxis, nitric oxide transport, patterning of blood vessels, peptide hormone secretion, phosphoinositide 3-kinase cascade, positive regulation of cardiac muscle hypertrophy, positive regulation of cell proliferation, positive regulation of cell size, positive regulation of endothelial cell migration, positive regulation of heart rate, positive regulation of hormone secretion, positive regulation of JUN kinase activity, positive regulation of mitosis, positive regulation of nitric oxide biosynthetic process, positive regulation of sarcomere organization, positive regulation of smooth muscle cell proliferation, positive regulation of smooth muscle contraction, prostaglandin biosynthetic process, protein kinase C deactivation, protein kinase cascade, regulation of blood pressure, regulation of blood vessel size, regulation of pH, regulation of systemic arterial blood pressure by endothelin, regulation of vasoconstriction, respiratory gaseous exchange, response to hypoxia, rhythmic excitation, skeletal system development, vasoconstriction, vein smooth muscle contraction
Literature References
- 12374743Goruppi S, Bonventre JV, Kyriakis JM. Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy.EMBO J 2002 Oct 15;21(20):5427-5436
- 17974986Bien S, Riad A, Ritter CA, Gratz M, Olshausen F, Westermann D, Grube M, Krieg T, Ciecholewski S, Felix SB, Staudt A, Schultheiss HP, Ewert R, Völker U, Tschöpe C, Kroemer HK. The endothelin receptor blocker bosentan inhibits Doxorubicin-induced cardiomyopathy.Cancer Res 2007 Nov 01;67(21):10428-35
- 17872473Yang R, Barouch LA. Leptin signaling and obesity: cardiovascular consequences.Circ Res 2007 Sep 14;101(6):545-59 View 3090 categorized literature findings and their references in IPA
Molecular Functions
endothelin A receptor binding, endothelin B receptor binding, hormone activity, protein binding, receptor binding
Subcellular Locations
brush border, cell surface, cellular membrane, cytoplasm, extracellular space, granules, membrane fraction, secretory granules, secretory vesicles, vesicles
