CDKN1B - cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Entrez Gene Name: cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Entrez GeneID: Human(1027)
, Mouse(12576), Rat(83571)
, Mouse(12576), Rat(83571) Synonyms: AA408329, AI843786, Cdki1b, CDKN1B, CDKN4, CYCLIN-DEPENDENT KINASE INHIBITOR P27, KIP1, MEN1B, MEN4, P27, P27kip, P27KIP1, P28-ICK
Gene Summary
- Human (1027): This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq]
- Rat (83571): inhibits the activity of cyclin-CDK complexes and plays a role in cell cycle control [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
autophagic cell death, cell cycle, cell cycle arrest, cell death, G1/S transition of mitotic cell cycle, induction of apoptosis, inner ear development, negative regulation of cell growth, negative regulation of cell motion, negative regulation of cell proliferation, negative regulation of cyclin-dependent protein kinase activity, negative regulation of epithelial cell proliferation, negative regulation of phosphorylation, positive regulation of cell proliferation, positive regulation of microtubule polymerization, potassium ion transport, regulation of cyclin-dependent protein kinase activity, response to amino acid stimulus, response to cadmium ion, response to drug, response to estradiol stimulus, response to glucose stimulus, response to hypoxia, response to organic cyclic substance, response to peptide hormone stimulus, response to stress, sensory perception of sound
Literature References
- 17254966Grimmler M, Wang Y, Mund T, Cilensek Z, Keidel EM, Waddell MB, Jäkel H, Kullmann M, Kriwacki RW, Hengst L. Cdk-Inhibitory Activity and Stability of p27(Kip1) Are Directly Regulated by Oncogenic Tyrosine Kinases.Cell 2007 Jan 26;128(2):269-80
- 16391232Besson A, Gurian-West M, Chen X, Kelly-Spratt KS, Kemp CJ, Roberts JM. A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression.Genes Dev 2006 Jan 01;20(1):47-64
- 16189514Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network.Nature 2005 Oct 20;437(7062):1173-8 View 5464 categorized literature findings and their references in IPA
Molecular Functions
cyclin-dependent protein kinase inhibitor activity, kinase activity, protein binding, protein complex binding, protein kinase inhibitor activity, transforming growth factor beta receptor, cytoplasmic mediator activity
- Antiproliferative Role of Somatostatin Receptor 2
- Prostate Cancer Signaling
- Chronic Myeloid Leukemia Signaling
- 14-3-3-mediated Signaling
- Molecular Mechanisms of Cancer
- PTEN Signaling
- Cell Cycle: G1/S Checkpoint Regulation
- Aryl Hydrocarbon Receptor Signaling
- Pancreatic Adenocarcinoma Signaling
- PI3K/AKT Signaling
- VDR/RXR Activation
- Small Cell Lung Cancer Signaling
- Neuregulin Signaling
Protein Domains
3-10 helix, cyclin-binding domain, Cyclin-dependent kinase binding domain, cyclin-dependent protein kinase inhibitor, nuclear localization sequence, protein binding, TGF beta receptor cytoplasmic mediator
Subcellular Locations
cytoplasm, cytoplasmic fraction, cytosol, cytosolic fraction, nuclear fraction, nucleoli, nucleus
