SMARCA4 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Entrez Gene Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Entrez GeneID: Human(6597)
, Mouse(20586), Rat(171379)
, Mouse(20586), Rat(171379) Synonyms: BAF190, BRG-1, FLJ39786, HP1-BP72, hSNF2b, SMARCA4, SNF2, SNF2-BETA, SNF2B, SNF2L4, SNF2LB, SW1/SNF, SWI2
Gene Summary
- Human (6597): The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Rat (171379): mouse homolog is a catalytic subunit of mammalian chromatin-remodeling complexes [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
ATP-dependent chromatin remodeling, blastocyst growth, blastocyst hatching, chromatin remodeling, embryonic hindlimb morphogenesis, epidermis morphogenesis, extracellular matrix organization, forebrain development, glial cell fate determination, heart development, heart trabecula formation, hindbrain development, keratinocyte differentiation, methylation-dependent chromatin silencing, negative regulation of S phase of mitotic cell cycle, negative regulation of specific transcription from RNA polymerase II promoter, negative regulation of transcription from RNA polymerase II promoter, nucleosome assembly, nucleosome disassembly, positive regulation of specific transcription from RNA polymerase II promoter, positive regulation of transcription factor activity, regulation of transcription, regulation of transcription, DNA-dependent, vasculogenesis
Cellular Components
heterochromatin, nuclear euchromatin, nucleolus, nucleus, perichromatin fibrils, soluble fraction, SWI/SNF complex
Literature References
- 16717115Zhang F, Boothby M. T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent.J Exp Med 2006 Jun 12;203(6):1493-505
- 16287714Bultman SJ, Gebuhr TC, Magnuson T. A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in {beta}-globin expression and erythroid development.Genes Dev 2005 Dec 01;19(23):2849-61
- 16024661Seo S, Herr A, Lim JW, Richardson GA, Richardson H, Kroll KL. Geminin regulates neuronal differentiation by antagonizing Brg1 activity.Genes Dev 2005 Jul 15;19(14):1723-34 View 1768 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ATPase activity, chromatin binding, DNA binding, DNA-dependent ATPase activity, helicase activity, histone binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, identical protein binding, nucleotide binding, p53 binding, protein binding, protein N-terminus binding, transcription activator activity, transcription factor binding
Protein Domains
arginine-lysine rich domain, ATPase, bromodomain, chromatin binding, helicase, LXCXE binding site, N-terminal domain, protein binding, protein N-terminus binding, protein self binding, transcription co-activator, transcription factor, transcription factor binding, transcription regulator
Subcellular Locations
cytoplasm, intranuclear region, nuclear bodies, nuclear foci, nuclear fraction, nuclear matrix fraction, nucleoplasm, nucleus
