GRIN2C - glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Entrez Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Entrez GeneID: Human(2905)
, Mouse(14813), Rat(24411)
, Mouse(14813), Rat(24411) Synonyms: GRIN2C, NMDAR2C, Nr2, NR2C
Gene Summary
- Rat (24411): subunit that in combination with NMDAR1 displays NMDA receptor activity; may contribute to NMDA receptor functional diversity [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
directional locomotion, glutamate signaling pathway, ion transport, locomotory behavior, negative regulation of protein catabolic process, neuromuscular process controlling balance, protein localization, regulation of excitatory postsynaptic membrane potential, regulation of membrane potential, regulation of synaptic plasticity, response to wounding, startle response, transport
Cellular Components
cell junction, integral to membrane, integral to plasma membrane, membrane, N-methyl-D-aspartate selective glutamate receptor complex, plasma membrane, postsynaptic density, postsynaptic membrane, synapse
Literature References
- 17329232Carter CJ. EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?Schizophr Bull 2007 Nov 01;33(6):1343-53
- 17188796Fan MM, Raymond LA. N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease.Prog Neurobiol 2007 Apr 01;81(5-6):272-93
- 11144360Ehlers MD. Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting.Neuron 2000 Nov 1;28(2):511-25 View 790 categorized literature findings and their references in IPA
Molecular Functions
calcium ion binding, cation channel activity, extracellular-glutamate-gated ion channel activity, ion channel activity, ionotropic glutamate receptor activity, magnesium ion binding, N-methyl-D-aspartate selective glutamate receptor activity, PDZ domain binding, protein binding, protein N-terminus binding, receptor activity
Protein Domains
carboxy terminal domain, cation channel, cytoplasmic domain, extracellular ligand binding domain, ion channel, ionotropic glutamate receptor, N-methyl-D-aspartate selective glutamate receptor, PDZ-domain binding, protein binding, protein N-terminus binding
