CHRNA9 - cholinergic receptor, nicotinic, alpha 9
Entrez Gene Name: cholinergic receptor, nicotinic, alpha 9
Entrez GeneID: Human(55584)
, Mouse(231252), Rat(65024)
, Mouse(231252), Rat(65024) Synonyms: 2410015I05Rik, Acra9, Alpha9 AChR, CHRNA9, EG666827, HSA243342, MGC142109, MGC142135, Nachr alpha 9, NACHRA9
Gene Summary
- Human (55584): This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells. [provided by RefSeq]
- Rat (65024): forms an acetylcholine activated homomeric receptor-channel complex; may modulate encoding of auditory stimuli in cochlear hair cells [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
calcium ion transport, cation transport, detection of mechanical stimulus involved in sensory perception of sound, inner ear morphogenesis, sensory perception of sound
Cellular Components
cell junction, integral to membrane, membrane, nicotinic acetylcholine-gated receptor-channel complex, plasma membrane, postsynaptic membrane, synapse
Literature References
- 15155845Salminen O, Murphy KL, McIntosh JM, Drago J, Marks MJ, Collins AC, Grady SR. Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.Mol Pharmacol 2004 Jun 01;65(6):1526-35
- 9442882Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases.Annu Rev Cell Dev Biol 1997;13:513-609
- 12069578Molles BE, Tsigelny I, Nguyen PD, Gao SX, Sine SM, Taylor P. Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface site.Biochemistry 2002 Jun 25;41(25):7895-906 View 392 categorized literature findings and their references in IPA
Molecular Functions
calcium channel activity, calcium ion binding, extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, nicotinic acetylcholine-activated cation-selective channel activity, receptor activity
Protein Domains
extracellular ligand binding domain, neurotransmitter-gated ion channel ligand binding domain, nicotinic acetylcholine-activated cation-selective channel, transmembrane receptor
