FGF9 - fibroblast growth factor 9 (glia-activating factor)
Entrez Gene Name: fibroblast growth factor 9 (glia-activating factor)
Entrez GeneID: Human(2254)
, Mouse(14180), Rat(25444)
, Mouse(14180), Rat(25444) Synonyms: Eks, FGF9, GAF, glia-activating factor, HBFG-9, MGC119914, MGC119915
Gene Summary
- Human (2254): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq]
- Rat (25444): human homolog is a heparin-binding growth factor [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
angiogenesis, cell differentiation, cell proliferation, cell-cell signaling, chondrocyte differentiation, embryonic gut development, embryonic limb morphogenesis, embryonic skeletal system development, fibroblast growth factor receptor signaling pathway, inner ear morphogenesis, lung development, male gonad development, male sex determination, multicellular organismal development, negative regulation of Wnt receptor signaling pathway, osteoblast differentiation, positive regulation of cardiac muscle cell proliferation, positive regulation of cell proliferation, positive regulation of epithelial cell proliferation, positive regulation of fibroblast growth factor receptor signaling pathway, positive regulation of MAPKKK cascade, positive regulation of mesenchymal cell proliferation, positive regulation of smoothened signaling pathway, positive regulation of vascular endothelial growth factor receptor signaling pathway, protein import into nucleus, regulation of timing of cell differentiation, signal transduction
Literature References
- 17494997Drummond AE, Tellbach M, Dyson M, Findlay JK. Fibroblast growth factor-9, a local regulator of ovarian function.Endocrinology 2007 Aug 01;148(8):3711-21
- 11290325Colvin JS, Green RP, Schmahl J, Capel B, Ornitz DM. Male-to-female sex reversal in mice lacking fibroblast growth factor 9.Cell 2001 Mar 23;104(6):875-89
- 16373332McDowell LM, Frazier BA, Studelska DR, Giljum K, Chen J, Liu J, Yu K, Ornitz DM, Zhang L. Inhibition or Activation of Apert Syndrome FGFR2 (S252W) Signaling by Specific Glycosaminoglycans.J Biol Chem 2006 Mar 17;281(11):6924-30 View 308 categorized literature findings and their references in IPA
Molecular Functions
fibroblast growth factor receptor binding, growth factor activity, heparin binding
Subcellular Locations
basement membrane, cytoplasm, extracellular space, Golgi apparatus, perinuclear region
