ADRB2 - adrenergic, beta-2-, receptor, surface
Entrez Gene Name: adrenergic, beta-2-, receptor, surface
Entrez GeneID: Human(154)
, Mouse(11555), Rat(24176)
, Mouse(11555), Rat(24176) Synonyms: ADRB2, ADRB2R, ADRBR, Adrenergic Receptor Beta 2, B2AR, BADM, BAR, BETA 2 ADRENERGIC RECEPTOR, Beta-2 adrenoceptor, Beta-2 receptor, BETA2-AR, Gpcr7
Gene Summary
- Human (154): This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq]
- Rat (24176): binds adrenergic receptor agonist zinterol; plays a role in G-protein coupled receptor regulation of calcium channel current [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of adenylate cyclase activity by G-protein signaling pathway, activation of transmembrane receptor protein tyrosine kinase activity, bone resorption, brown fat cell differentiation, desensitization of G-protein coupled receptor protein signaling pathway by arrestin, diet induced thermogenesis, endosome to lysosome transport, G-protein coupled receptor protein signaling pathway, heat generation, negative regulation of calcium ion transport via voltage-gated calcium channel activity, negative regulation of inflammatory response, negative regulation of multicellular organism growth, negative regulation of ossification, negative regulation of smooth muscle contraction, positive regulation of apoptosis, positive regulation of bone mineralization, positive regulation of cell proliferation, positive regulation of heart contraction, positive regulation of MAPKKK cascade, positive regulation of potassium ion transport, positive regulation of skeletal muscle growth, positive regulation of sodium ion transport, positive regulation of transcription from RNA polymerase II promoter, positive regulation of vasodilation, receptor-mediated endocytosis, regulation of sensory perception of pain, regulation of sodium ion transport, regulation of systemic arterial blood pressure by norepinephrine-epinephrine, response to cold, signal transduction, vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
Cellular Components
apical plasma membrane, axon, caveola, dendrite, endosome, integral to membrane, integral to plasma membrane, intracellular part, lysosome, membrane, membrane fraction, microsome, nucleus, plasma membrane, receptor complex, sarcolemma
Literature References
- 9759500Pitcher JA, Freedman NJ, Lefkowitz RJ. G protein-coupled receptor kinases.Annu Rev Biochem 1998;67:653-92
- 9560162Hall RA, Premont RT, Chow CW, Blitzer JT, Pitcher JA, Claing A, Stoffel RH, Barak LS, Shenolikar S, Weinman EJ, Grinstein S, Lefkowitz RJ. The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.Nature 1998 Apr 9;392(6676):626-30
- 17515456Kim SM, Chen L, Faulhaber-Walter R, Oppermann M, Huang Y, Mizel D, Briggs JP, Schnermann J. Regulation of renin secretion and expression in mice deficient in beta1- and beta2-adrenergic receptors.Hypertension 2007 Jul 01;50(1):103-9 View 2243 categorized literature findings and their references in IPA
Molecular Functions
adenylate cyclase binding, adrenoceptor activity, beta2-adrenergic receptor activity, dopamine binding, drug binding, epinephrine binding, G-protein coupled receptor activity, norepinephrine binding, PDZ domain binding, potassium channel regulator activity, protein binding, protein complex binding, protein homodimerization activity, receptor activity, signal transducer activity
Protein Domains
adenylate cyclase binding, beta2-adrenergic receptor, carboxy terminal domain, cytoplasmic loop, drug binding, G-protein coupled receptor, helical domain, PDZ-domain binding, potassium channel regulator, protein binding, protein homodimerization, tail domain
Subcellular Locations
apical membrane, axodendritic synapses, axons, axosomatic synapses, caveolae, caveolae fraction, cell body, cell borders, cell surface, cellular membrane, cilia, cytoplasm, dendritic spines, endoplasmic reticulum, endosomes, Golgi apparatus, lysosome, membrane fraction, plasma membrane
