PMCH - pro-melanin-concentrating hormone
Entrez Gene Name: pro-melanin-concentrating hormone
Entrez GeneID: Human(5367)
, Mouse(110312), Rat(24659)
, Mouse(110312), Rat(24659) Synonyms: A230109K23RIK, MCH, Melanin Concentrating Hormone, PMCH
Gene Summary
- Rat (24659): cyclic neuropeptide; induces hippocampal synaptic transmission [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell differentiation, drinking behavior, elevation of cytosolic calcium ion concentration, feeding behavior, glucose homeostasis, lactation, learning or memory, multicellular organismal development, negative regulation of blood pressure, negative regulation of synaptic transmission, dopaminergic, neuropeptide signaling pathway, positive regulation of circadian sleep/wake cycle, REM sleep, regulation of heart rate, regulation of neuronal synaptic plasticity, response to cold, signal transduction, spermatogenesis, synaptic transmission
Literature References
- 10069329Elmquist JK, Elias CF, Saper CB. From lesions to leptin: hypothalamic control of food intake and body weight.Neuron 1999 Feb 1;22(2):221-32
- 14573562Gao XB, Ghosh PK, van den Pol AN. Neurons synthesizing melanin-concentrating hormone identified by selective reporter gene expression after transfection in vitro: transmitter responses.J Neurophysiol 2003 Dec 01;90(6):3978-85
- 12933668Abbott CR, Kennedy AR, Wren AM, Rossi M, Murphy KG, Seal LJ, Todd JF, Ghatei MA, Small CJ, Bloom SR. Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone.Endocrinology 2003 Sep;144(9):3943-9 View 774 categorized literature findings and their references in IPA
Molecular Functions
hormone activity, melanin-concentrating hormone activity, type 1 melanin-concentrating hormone receptor binding
Subcellular Locations
axon terminals, axons, cell body, cytoplasm, dendrites, dendritic branches, dendritic spines, extracellular space, Golgi apparatus, perikaryon, rough endoplasmatic reticulum, trans face of the Golgi apparatus
