CAPN1 - calpain 1, (mu/I) large subunit
Entrez Gene Name: calpain 1, (mu/I) large subunit
Entrez GeneID: Human(823)
, Mouse(12333), Rat(29153)
, Mouse(12333), Rat(29153) Synonyms: CALCIUM ACTIVATED NEUTRAL PROTEASE, CALPAIN I, CALPAIN1, CANP, CANP1, CANPL1, Capa-1, CAPN1, MU CALPAIN, MU-CALPIN, muCANP, muCL
Gene Summary
- Human (823): The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. [provided by RefSeq]
- Rat (29153): calcium-dependent protease that may be involved in experimental allergic encephalomyelitis (EAE) [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Literature References
- 14556717Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death.Neuron 2003 Oct 09;40(2):401-13
- 17332428Galvez AS, Diwan A, Odley AM, Hahn HS, Osinska H, Melendez JG, Robbins J, Lynch RA, Marreez Y, Dorn GW. Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis.Circ Res 2007 Apr 13;100(7):1071-8
- 17192410Nuzzi PA, Senetar MA, Huttenlocher A. Asymmetric Localization of Calpain 2 during Neutrophil Chemotaxis.Mol Biol Cell 2007 Mar 01;18(3):795-805 View 771 categorized literature findings and their references in IPA
Molecular Functions
calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, cytoskeletal protein binding, hydrolase activity, peptidase activity, protein binding
Protein Domains
calcium ion binding, Calpain, calpain domain III, cytoskeletal protein binding, EF-Hand, N-terminal domain, peptidase, protein binding
Subcellular Locations
cell body, cellular membrane, cytoplasm, cytosolic fraction, Golgi apparatus, mitochondria, mitochondrial intermembrane space, neurites, plasma membrane
