GABRA2 - gamma-aminobutyric acid (GABA) A receptor, alpha 2
Entrez Gene Name: gamma-aminobutyric acid (GABA) A receptor, alpha 2
Entrez GeneID: Human(2555)
, Mouse(14395), Rat(289606)
, Mouse(14395), Rat(289606) Synonyms: C630048P16Rik, FLJ97076, Gaba A receptor alpha-2, GABA A RECEPTOR SUBUNIT ALPHA 2, GABRA2, MGC140832
Gene Summary
- Human (2555): GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
- Rat (289606): may act as subunits in GABA-A receptors with benzodiazepine II binding characteristics [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Biological Process
chloride transport, gamma-aminobutyric acid signaling pathway, ion transport, neurotransmitter transport, regulation of neurotransmitter levels, transport
Cellular Components
cell junction, integral to membrane, integral to synaptic vesicle membrane, membrane, plasma membrane, postsynaptic membrane, synapse
Literature References
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 10196563Essrich C, Lorez M, Benson JA, Fritschy JM, Lüscher B. Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin.Nat Neurosci 1998 Nov 1;1(7):563-71
- 12077177Brünig I, Suter A, Knuesel I, Lüscher B, Fritschy JM. GABAergic terminals are required for postsynaptic clustering of dystrophin but not of GABA(A) receptors and gephyrin.J Neurosci 2002 Jun 15;22(12):4805-13 View 275 categorized literature findings and their references in IPA
Molecular Functions
benzodiazepine receptor activity, chloride channel activity, chloride ion binding, extracellular ligand-gated ion channel activity, GABA-A receptor activity, ion channel activity, neurotransmitter receptor activity, receptor activity
Protein Domains
benzodiazepine receptor, extracellular ligand binding domain, GABA-A receptor, intracellular domain, ion channel, neurotransmitter-gated ion channel ligand binding domain
Subcellular Locations
cell body, cellular membrane, dendrites, membrane fraction, plasma membrane, synapse
