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CHRNA6 - cholinergic receptor, nicotinic, alpha 6
Entrez Gene Name: cholinergic receptor, nicotinic, alpha 6
Entrez GeneID: Human(8973), Mouse(11440), Rat(81721)
Synonyms: Acra6, ALPHA6 NACHR, CHNRA6, CHRNA6, nAChR alpha6, Nica6

Gene Summary

  • Rat (81721): may form a nicotinic acetylcholine receptor; may play a role in fast synaptic transmission [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • AchR
  • Ras
  • nicotine
View all 13 in IPA
Regulated by:
  • nicotine
  • acetylcholine
  • galanthamine
View all 42 in IPA
Binds:
  • epibatidine
  • acetylcholine
  • pipecuronium
View all 35 in IPA
Role in cell:
  • depolarization
  • damage
  • long term depression in
View all 5 in IPA
Disease:
  • lung cancer
  • experimental autoimmune myasthenia gravis
  • Alzheimer's disease
View all 32 in IPA

Biological Process

ion transport, membrane depolarization, protein heterooligomerization, regulation of dopamine secretion, signal transduction, synaptic transmission, transport

Cellular Components

cell junction, integral to membrane, membrane, membrane fraction, nicotinic acetylcholine-gated receptor-channel complex, plasma membrane, postsynaptic membrane, synapse

Literature References

  • 15213299Moretti M, Vailati S, Zoli M, Lippi G, Riganti L, Longhi R, Viegi A, Clementi F, Gotti C. Nicotinic Acetylcholine Receptor Subtypes Expression during Rat Retina Development and Their Regulation by Visual Experience.Mol Pharmacol 2004 Jul 01;66(1):85-96
  • 15155845Salminen O, Murphy KL, McIntosh JM, Drago J, Marks MJ, Collins AC, Grady SR. Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.Mol Pharmacol 2004 Jun 01;65(6):1526-35
  • 9442882Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases.Annu Rev Cell Dev Biol 1997;13:513-609
    • View 361 categorized literature findings and their references in IPA

Molecular Functions

acetylcholine receptor activity, drug binding, extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, nicotinic acetylcholine-activated cation-selective channel activity, protein binding, receptor activity

Pathways

Protein Domains

acetylcholine receptor, extracellular ligand binding domain, neurotransmitter-gated ion channel ligand binding domain, nicotinic acetylcholine-activated cation-selective channel, protein binding, transmembrane receptor

Subcellular Locations

cellular membrane, plasma membrane

IPA Extras