PDYN - prodynorphin
Entrez Gene Name: prodynorphin
Entrez GeneID: Human(5173)
, Mouse(18610), Rat(29190)
, Mouse(18610), Rat(29190) Synonyms: Leu5 -enkephalin, ALPHA NEOENDORPHIN, Dyn, DYNORPHIN, DYNORPHIN A, DYNORPHIN B, MGC26418, PDYN, PENKB, PRODYN, PRODYNORPHIN, Proenkephalin B
Gene Summary
- Human (5173): The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. [provided by RefSeq]
- Rat (29190): expression in hippocampus increases in response to traumatic brain injury; may play a role in regulatio of neurotransmitter release [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
neuropeptide signaling pathway, regulation of neurotransmitter secretion, synaptic transmission
Literature References
- 11792319Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J, Sarosi I, Woodgett JR, Oliveira-dos-Santos AJ, Ikura M, van der Kooy D, Salter MW, Penninger JM. DREAM is a critical transcriptional repressor for pain modulation.Cell 2002 Jan 11;108(1):31-43
- 12438557Boudarine M, Yegorov O, Sterling-Dubrovsky A, Devi LA, Berman Y. Developmental changes in opioid peptides and their receptors in Cpe(fat)/Cpe(fat) mice lacking peptide processing enzyme carboxypeptidase E.J Pharmacol Exp Ther 2002 Dec;303(3):1317-24
- 11803449Hurd YL. Subjects with major depression or bipolar disorder show reduction of prodynorphin mRNA expression in discrete nuclei of the amygdaloid complex.Mol Psychiatry 2002 Jan 01;7(1):75-81 View 408 categorized literature findings and their references in IPA
