P2RX3 - purinergic receptor P2X, ligand-gated ion channel, 3
Entrez Gene Name: purinergic receptor P2X, ligand-gated ion channel, 3
Entrez GeneID: Human(5024)
, Mouse(228139), Rat(81739)
, Mouse(228139), Rat(81739) Synonyms: MGC129956, MGC28163, P2RX3, P2X3
Gene Summary
- Human (5024): The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq]
- Rat (81739): ligand gated, cation-selective ion channel that is a receptor for ATP [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
behavioral response to pain, cation transport, ion transport, neuromuscular synaptic transmission, peristalsis, positive regulation of calcium ion transport into cytosol, positive regulation of calcium-mediated signaling, protein homooligomerization, regulation of action potential in neuron, regulation of synaptic plasticity, response to ATP, response to carbohydrate stimulus, response to cold, response to heat, response to hypoxia, response to organic substance, response to stimulus, response to temperature stimulus, sensory perception of taste, signal transduction, synaptic transmission, transport, urinary bladder smooth muscle contraction
Cellular Components
axon, cell soma, dendritic spine, Golgi apparatus, integral to membrane, integral to plasma membrane, intracellular part, membrane, membrane fraction, membrane raft, neuron projection, rough endoplasmic reticulum, synaptosome, terminal button
Literature References
- 11069181Cockayne DA, Hamilton SG, Zhu QM, Dunn PM, Zhong Y, Novakovic S, Malmberg AB, Cain G, Berson A, Kassotakis L, Hedley L, Lachnit WG, Burnstock G, McMahon SB, Ford AP. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice.Nature 2000 Oct 26;407(6807):1011-5
- 11069182Souslova V, Cesare P, Ding Y, Akopian AN, Stanfa L, Suzuki R, Carpenter K, Dickenson A, Boyce S, Hill R, Nebenuis-Oosthuizen D, Smith AJ, Kidd EJ, Wood JN. Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors.Nature 2000 Oct 26;407(6807):1015-7
- 16815477Sah DW. Therapeutic potential of RNA interference for neurological disorders.Life Sci 2006 Oct 04;79(19):1773-80 View 200 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ATP-gated cation channel activity, ion channel activity, protein heterodimerization activity, protein homodimerization activity, purinergic nucleotide receptor activity, receptor activity
