PRKCH - protein kinase C, eta
Entrez Gene Name: protein kinase C, eta
Entrez GeneID: Human(5583)
, Mouse(18755), Rat(81749)
, Mouse(18755), Rat(81749) Synonyms: MGC26269, MGC5363, MGC93383, nPKC-eta, PKC ETA, PKC-L, PKCH, PRKCH, PRKCL
Gene Summary
- Human (5583): Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq]
- Rat (81749): catalyzes the phospholipid and TPA-dependent, calcium independent phosphorylation of several peptide substrates [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Literature References
- 17206144Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y. A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.Nat Genet 2007 02 1;39(2):212-7
- 10836144Sah VP, Seasholtz TM, Sagi SA, Brown JH. The role of Rho in G protein-coupled receptor signal transduction.Annu Rev Pharmacol Toxicol 2000;40:459-89
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49 View 2510 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, diacylglycerol binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein kinase C activity, protein serine/threonine kinase activity, transferase activity, zinc ion binding
- Androgen Signaling
- CXCR4 Signaling
- CREB Signaling in Neurons
- CCR5 Signaling in Macrophages
- Fc Epsilon RI Signaling
- Renin-Angiotensin Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Mechanisms of Viral Exit from Host Cells
- p70S6K Signaling
- Macropinocytosis Signaling
- Neuregulin Signaling
- Melatonin Signaling
- Endothelin-1 Signaling
- Synaptic Long Term Depression
- Type II Diabetes Mellitus Signaling
- Xenobiotic Metabolism Signaling
- HGF Signaling
- Natural Killer Cell Signaling
- IL-3 Signaling
- VDR/RXR Activation
- Factors Promoting Cardiogenesis in Vertebrates
- Thrombopoietin Signaling
- α-Adrenergic Signaling
- CCR3 Signaling in Eosinophils
- IL-12 Signaling and Production in Macrophages
- Axonal Guidance Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Synaptic Long Term Potentiation
- Nicotinate and Nicotinamide Metabolism
- mTOR Signaling
- IGF-1 Signaling
- G Beta Gamma Signaling
- Aldosterone Signaling in Epithelial Cells
- Hepatic Cholestasis
- Leukocyte Extravasation Signaling
- Cdc42 Signaling
- LPS-stimulated MAPK Signaling
- Virus Entry via Endocytic Pathways
- NRF2-mediated Oxidative Stress Response
- Cholecystokinin/Gastrin-mediated Signaling
- GNRH Signaling
- Insulin Receptor Signaling
- NF-κB Activation by Viruses
- RAR Activation
- Calcium-induced T Lymphocyte Apoptosis
- Prolactin Signaling
- 14-3-3-mediated Signaling
- Erythropoietin Signaling
- Glioma Signaling
- Growth Hormone Signaling
- IL-8 Signaling
- Corticotropin Releasing Hormone Signaling
- Tight Junction Signaling
- Inositol Phosphate Metabolism
- fMLP Signaling in Neutrophils
- Molecular Mechanisms of Cancer
- Thrombin Signaling
- Huntington's Disease Signaling
Protein Domains
Alcohol group acceptor phosphotransferase, C1 domain, C2 domain, catalytic domain, kinase, Protein kinase, protein kinase C, protein serine/threonine kinase, protein-tyrosine kinase
Subcellular Locations
cytoplasm, cytosol, detergent-soluble fraction, membrane fraction, perinuclear region
