CHRNB2 - cholinergic receptor, nicotinic, beta 2 (neuronal)
Entrez Gene Name: cholinergic receptor, nicotinic, beta 2 (neuronal)
Entrez GeneID: Human(1141)
, Mouse(11444), Rat(54239)
, Mouse(11444), Rat(54239) Synonyms: b 2-nAchR, ACETYLCHOLINE RECEPTOR BETA2, AChR beta2, Acrb-2, C030030P04Rik, CHRNB2, EFNL3, nAChR beta-2, nAChRB2, Narac Beta2, Nicotinic beta polypeptide 2
Gene Summary
- Human (1141): Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq]
- Rat (54239): co-assembles with the alpha 7 subunit to form a functional heteromeric nicotinic acetylcholine receptor [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
associative learning, B cell activation, behavioral response to nicotine, calcium ion transport, central nervous system neuron axonogenesis, central nervous system projection neuron axonogenesis, cognition, conditioned taste aversion, ion transport, lateral geniculate nucleus development, learning, locomotory behavior, membrane depolarization, memory, negative regulation of action potential, optic nerve morphogenesis, positive regulation of B cell proliferation, positive regulation of dopamine secretion, positive regulation of synaptic transmission, dopaminergic, protein heterooligomerization, regulation of action potential, regulation of circadian sleep/wake cycle, non-REM sleep, regulation of circadian sleep/wake cycle, REM sleep, regulation of dendrite morphogenesis, regulation of dopamine metabolic process, regulation of dopamine secretion, regulation of membrane potential, regulation of synaptic transmission, dopaminergic, regulation of synaptogenesis, response to cocaine, response to ethanol, response to hypoxia, response to nicotine, sensory perception of pain, sensory perception of sound, signal transduction, smooth muscle contraction, social behavior, synaptic transmission involved in micturition, synaptic transmission, cholinergic, transport, vestibulocochlear nerve development, visual learning, visual perception
Cellular Components
cell junction, external side of plasma membrane, integral to membrane, membrane, membrane fraction, nicotinic acetylcholine-gated receptor-channel complex, plasma membrane, postsynaptic membrane, synapse
Literature References
- 16738207Broad LM, Zwart R, Pearson KH, Lee M, Wallace L, McPhie GI, Emkey R, Hollinshead SP, Dell CP, Baker SR, Sher E. Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.J Pharmacol Exp Ther 2006 Sep 01;318(3):1108-17
- 16014729Ren XQ, Cheng SB, Treuil MW, Mukherjee J, Rao J, Braunewell KH, Lindstrom JM, Anand R. Structural determinants of alpha4beta2 nicotinic acetylcholine receptor trafficking.J Neurosci 2005 Jul 13;25(28):6676-86
- 15681842Arredondo J, Chernyavsky AI, Marubio LM, Beaudet AL, Jolkovsky DL, Pinkerton KE, Grando SA. Receptor-Mediated Tobacco Toxicity: Regulation of Gene Expression through {alpha}3{beta}2 Nicotinic Receptor in Oral Epithelial Cells.Am J Pathol 2005 Feb 01;166(2):597-613 View 633 categorized literature findings and their references in IPA
Molecular Functions
acetylcholine binding, acetylcholine receptor activity, drug binding, extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, nicotinic acetylcholine-activated cation-selective channel activity, protein binding, receptor activity
Protein Domains
acetylcholine receptor, extracellular ligand binding domain, neurotransmitter-gated ion channel ligand binding domain, nicotinic acetylcholine-activated cation-selective channel, protein binding, transmembrane receptor
Subcellular Locations
cell body, cell surface, cellular membrane, cytoplasm, plasma membrane, synaptosomes
