GABRA6 - gamma-aminobutyric acid (GABA) A receptor, alpha 6
Entrez Gene Name: gamma-aminobutyric acid (GABA) A receptor, alpha 6
Entrez GeneID: Human(2559)
, Mouse(14399), Rat(29708)
, Mouse(14399), Rat(29708) Synonyms: alpha6, Gaba A receptor alpha-6, GABRA6, MGC116903, MGC116904
Gene Summary
- Human (2559): GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq]
- Rat (29708): GABAA receptor subunit; part of a cerebellar receptor subtype, selective for antagonist of alcohol-induced motor incoordination and ataxia [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Biological Process
chloride transport, gamma-aminobutyric acid signaling pathway, ion transport, protein heterooligomerization, signal transduction, synaptic transmission, GABAergic, transport
Cellular Components
cell junction, cell soma membrane, dendrite, integral to membrane, integral to plasma membrane, membrane, plasma membrane, postsynaptic membrane, presynaptic membrane, receptor complex, synapse, synaptic cleft
Literature References
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 15466411Wang W, Stock RE, Gronostajski RM, Wong YW, Schachner M, Kilpatrick DL. A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression.J Biol Chem 2004 Dec 17;279(51):53491-7
- 17646167Payne HL, Connelly WM, Ives JH, Lehner R, Furtmuller B, Sieghart W, Tiwari P, Lucocq JM, Lees G, Thompson CL. GABAA {alpha}6-Containing Receptors Are Selectively Compromised in Cerebellar Granule Cells of the Ataxic Mouse, Stargazer.J Biol Chem 2007 Oct 05;282(40):29130-43 View 249 categorized literature findings and their references in IPA
Molecular Functions
benzodiazepine receptor activity, chloride channel activity, chloride ion binding, drug binding, extracellular ligand-gated ion channel activity, GABA-A receptor activity, GABA-gated chloride ion channel activity, inhibitory extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, receptor activity
Protein Domains
benzodiazepine receptor, chloride channel, drug binding, extracellular ligand binding domain, GABA-A receptor, inhibitory extracellular ligand-gated ion channel, intracellular domain, ion channel, neurotransmitter-gated ion channel ligand binding domain
