CENPE - centromere protein E, 312kDa
Entrez Gene Name: centromere protein E, 312kDa
Entrez GeneID: Human(1062)
, Mouse(229841), Rat(362044)
, Mouse(229841), Rat(362044) Synonyms: 312kDa, AU019344, BC049989, C530022J18, CENPE, KIF10
Gene Summary
- Human (1062): Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
attachment of spindle microtubules to kinetochore, cell cycle, cell division, establishment of protein localization, kinetochore assembly, microtubule-based movement, mitosis, mitotic cell cycle spindle assembly checkpoint, mitotic chromosome movement towards spindle pole, mitotic metaphase, mitotic metaphase plate congression, multicellular organismal development, positive regulation of attachment of spindle microtubules to kinetochore, positive regulation of mitotic metaphase/anaphase transition, positive regulation of protein kinase activity, regulation of developmental process, regulation of mitosis
Cellular Components
chromosome, centromeric region, microtubule, microtubule associated complex, nucleus, outer kinetochore of condensed chromosome, spindle
Literature References
- 17535814Liu D, Ding X, Du J, Cai X, Huang Y, Ward T, Shaw A, Yang Y, Hu R, Jin C, Yao X. Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment.J Biol Chem 2007 Jul 20;282(29):21415-24
- 11553716McEwen BF, Chan GK, Zubrowski B, Savoian MS, Sauer MT, Yen TJ. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells.Mol Biol Cell 2001 Sep 1;12(9):2776-89
- 9763420Chan GK, Schaar BT, Yen TJ. Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1.J Cell Biol 1998 Oct 5;143(1):49-63 View 172 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, kinetochore binding, microtubule motor activity, motor activity, nucleotide binding, protein binding, protein kinase binding
Protein Domains
ERM homology domain, microtubule binding domain, microtubule motor protein, motor domain, protein binding, tail domain, V0 functional domain
Subcellular Locations
central spindle, centromeres, Flemming body, kinetochores, midbody, mitotic spindle, nuclear scaffolds, nucleus
