PPP1R1B - protein phosphatase 1, regulatory (inhibitor) subunit 1B
Entrez Gene Name: protein phosphatase 1, regulatory (inhibitor) subunit 1B
Entrez GeneID: Human(84152)
, Mouse(19049), Rat(360616)
, Mouse(19049), Rat(360616) Synonyms: AU040756, DARPP, DARPP-32, Dopamine and camp regulated neuronal phosphoprotein, FLJ20940, MGC139723, PPP1R1B
Gene Summary
- Human (84152): Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990 [PubMed 2191086]) that also express dopamine D1 receptors (Walaas and Greengard, 1984 [PubMed 6319627]). The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions (Halpain et al., 1990 [PubMed 2153935]). Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984 [PubMed 6319627]); phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984 [PubMed 6087160]). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain et al., 1990 [PubMed 2153935]).[supplied by OMIM]
- Rat (360616): potent inhibitor of protein phosphatase 1 (PP1); may play a role in maintaining the levels of excitability of NMDA receptors [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
intracellular signaling cascade, negative regulation of female receptivity, signal transduction, transcription
Literature References
- 10669419Mani SK, Fienberg AA, O'Callaghan JP, Snyder GL, Allen PB, Dash PK, Moore AN, Mitchell AJ, Bibb J, Greengard P, O'Malley BW. Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice.Science 2000 Feb 11;287(5455):1053-6
- 10604473Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA, Tsai LH, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings HC, Nairn AC, Greengard P. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.Nature 1999 Dec 9;402(6762):669-71
- 17646043Schiffmann SN, Fisone G, Moresco R, Cunha RA, Ferré S. Adenosine A2A receptors and basal ganglia physiology.Prog Neurobiol 2007 Dec 01;83(5):277-92 View 493 categorized literature findings and their references in IPA
Molecular Functions
phosphoprotein phosphatase inhibitor activity, protein kinase inhibitor activity, protein serine/threonine phosphatase inhibitor activity
Protein Domains
phosphatase, Phosphoprotein phosphatase, protein kinase inhibitor, protein phosphatase inhibitor, RKKIQF motif, type 1 serine/threonine specific protein phosphatase inhibitor
