PXN - paxillin
Entrez Gene Name: paxillin
Entrez GeneID: Human(5829)
, Mouse(19303), Rat(360820)
, Mouse(19303), Rat(360820) Synonyms: AW108311, AW123232, FLJ16691, FLJ23042, PAX, PAXILLIN, PXN
Gene Summary
No Data Available
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPK activity, branching morphogenesis of a tube, cell adhesion, cell motion, cell-matrix adhesion, cellular response to reactive oxygen species, cytoskeleton organization, focal adhesion formation, integrin-mediated signaling pathway, lamellipodium assembly, peptidyl-tyrosine phosphorylation, signal complex assembly, signal transduction
Cellular Components
cell junction, cytoplasm, cytoskeleton, focal adhesion, lamellipodium, microtubule associated complex, plasma membrane
Literature References
- 15163412de Hoog CL, Foster LJ, Mann M. RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers.Cell 2004 05 28;117(5):649-62
- 12118253Fernandez-Valle C, Tang Y, Ricard J, Rodenas-Ruano A, Taylor A, Hackler E, Biggerstaff J, Iacovelli J. Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology.Nat Genet 2002 Aug 1;31(4):354-62
- 10836144Sah VP, Seasholtz TM, Sagi SA, Brown JH. The role of Rho in G protein-coupled receptor signal transduction.Annu Rev Pharmacol Toxicol 2000;40:459-89 View 1974 categorized literature findings and their references in IPA
Molecular Functions
BH4 domain binding, metal ion binding, protein binding, protein kinase binding, receptor signaling complex scaffold activity, vinculin binding, zinc ion binding
- Gα12/13 Signaling
- Axonal Guidance Signaling
- ERK/MAPK Signaling
- VEGF Signaling
- Ephrin Receptor Signaling
- Agrin Interactions at Neuromuscular Junction
- FAK Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Leukocyte Extravasation Signaling
- HGF Signaling
- IGF-1 Signaling
- ILK Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Actin Cytoskeleton Signaling
- Integrin Signaling
Protein Domains
LIM domain, paxillin LD motif, protein binding, protein kinase binding, receptor signaling complex scaffold protein, vinculin binding
Subcellular Locations
actin stress fibers, basal membrane, basolateral cell surfaces, cell body, cell membrane leading edge, cell membrane-lagging edges, cell periphery, cell-cell contacts, cell-matrix adherens junctions, cell-matrix contacts, cellular membrane, cytoplasm, cytoskeletal fraction, cytoskeleton, cytosol, cytosolic fraction, endoplasmic reticulum, filopodia, focal adhesions, focal complexes, growth cone, insoluble fractions, lamellipodia, membrane ruffles, microtubule organizing centers, neurites, nuclear matrix fraction, perinuclear region, plasma membrane, soluble fraction
