PDGFA - platelet-derived growth factor alpha polypeptide
Entrez Gene Name: platelet-derived growth factor alpha polypeptide
Entrez GeneID: Human(5154)
, Mouse(18590), Rat(25266)
, Mouse(18590), Rat(25266) Synonyms: Pdgf a-chain, PDGF1, PDGFA, PDGFACP
Gene Summary
- Human (5154): The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq]
- Rat (25266): alpha chain of platelet derived growth factor; acts as a homodimer or heterodimer with PDGF beta to activate PDGF receptors [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
actin cytoskeleton organization, alveolus development, angiogenesis, cell activation, cell projection assembly, cell proliferation, cell-cell signaling, embryonic development, hair follicle development, inner ear development, negative chemotaxis, negative regulation of phosphatidylinositol biosynthetic process, negative regulation of platelet activation, organ morphogenesis, platelet-derived growth factor receptor signaling pathway, positive regulation of cell migration, positive regulation of cell proliferation, positive regulation of DNA replication, positive regulation of fibroblast proliferation, positive regulation of mesenchymal cell proliferation, regulation of actin cytoskeleton organization, regulation of peptidyl-tyrosine phosphorylation, regulation of smooth muscle cell migration, response to drug, response to estradiol stimulus, response to hypoxia, response to inorganic substance, response to organic substance, response to retinoic acid, skin development, transforming growth factor beta receptor signaling pathway, wound healing
Cellular Components
cell surface, extracellular region, extracellular space, membrane, microvillus, platelet dense granule lumen
Literature References
- 15361870Ding H, Wu X, Bostrom H, Kim I, Wong N, Tsoi B, O'Rourke M, Koh GY, Soriano P, Betsholtz C, Hart TC, Marazita ML, Field LL, Tam PP, Nagy A. A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.Nat Genet 2004 10 1;36(10):1111-6
- 11157165Tang DG, Tokumoto YM, Apperly JA, Lloyd AC, Raff MC. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells.Science 2001 Feb 2;291(5505):868-71
- 10966456Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology.Annu Rev Biochem 2000;69:145-82 View 2562 categorized literature findings and their references in IPA
Molecular Functions
cell surface binding, collagen binding, growth factor activity, platelet-derived growth factor binding, platelet-derived growth factor receptor binding, protein heterodimerization activity, protein homodimerization activity
- VDR/RXR Activation
- Glioma Signaling
- Actin Cytoskeleton Signaling
- Macropinocytosis Signaling
- PDGF Signaling
- Clathrin-mediated Endocytosis Signaling
- Human Embryonic Stem Cell Pluripotency
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Sphingosine-1-phosphate Signaling
- Axonal Guidance Signaling
- Ephrin Receptor Signaling
- PPAR Signaling
Protein Domains
collagen binding, growth factor, platelet-derived growth factor receptor binding, protein heterodimerization, protein homodimerization
Subcellular Locations
alpha granules, axons, cell body, cytoplasm, cytoplasmic vesicles, dendrites, extracellular space
