EIF2S1 - eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Entrez Gene Name: eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Entrez GeneID: Human(1965)
, Mouse(13665), Rat(54318)
, Mouse(13665), Rat(54318) Synonyms: 0910001O23Rik, 2410026C18Rik, 35kDa, EIF-2, EIF-2A, EIF-2ALPHA, EIF2S1, Eukaryotic Translation Initiation Factor 2 Alpha Subunit, MGC93488
Gene Summary
- Human (1965): The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD, MIM 603908), and gamma (52 kD, MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM]
- Rat (54318): subunit of translational initiation factor eIF-2; forms ternary complex with methionyl-tRNAi and GTP and promotes the binding of the initiator tRNA to 40 S ribosomal subunits [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
protein amino acid autophosphorylation, regulation of translation, regulation of translational initiation in response to stress, translation
Cellular Components
cytoplasm, cytosol, eukaryotic translation initiation factor 2 complex, eukaryotic translation initiation factor 2B complex, nucleus, polysome
Literature References
- 17329232Carter CJ. EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?Schizophr Bull 2007 Nov 01;33(6):1343-53
- 17451862García MA, Meurs EF, Esteban M. The dsRNA protein kinase PKR: virus and cell control.Biochimie 2007 Jun 01;89(6-7):799-811
- 14966282Perkins DJ, Barber GN. Defects in Translational Regulation Mediated by the alpha Subunit of Eukaryotic Initiation Factor 2 Inhibit Antiviral Activity and Facilitate the Malignant Transformation of Human Fibroblasts.Mol Cell Biol 2004 Mar 01;24(5):2025-40 View 581 categorized literature findings and their references in IPA
