PRKCQ - protein kinase C, theta
Entrez Gene Name: protein kinase C, theta
Entrez GeneID: Human(5588)
, Mouse(18761), Rat(85420)
, Mouse(18761), Rat(85420) Synonyms: A130035A12Rik, AW494342, MGC126514, MGC141919, nPKC-theta, PKC-0, PKC-THETA, Pkcq, PRKCQ, PRKCT
Gene Summary
- Human (5588): Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq]
- Rat (85420): mediates the integration of TCR- and CD28-derived signals leading to NFk-B transcription factor activation necessary for efficient IL-2 production and T cell proliferation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
aging, intracellular signaling cascade, membrane protein ectodomain proteolysis, neuron differentiation, positive regulation of filopodium assembly, positive regulation of interleukin-2 biosynthetic process, positive regulation of NF-kappaB import into nucleus, positive regulation of NF-kappaB transcription factor activity, positive regulation of protein secretion, positive regulation of stress fiber formation, positive regulation of T cell activation, positive regulation of T cell proliferation, protein amino acid phosphorylation, regulation of cell growth, regulation of G2/M transition of mitotic cell cycle, regulation of vasoconstriction, respiratory burst, response to glucose stimulus, response to heat, response to hypoxia, response to insulin stimulus, response to organic cyclic substance, tissue regeneration
Cellular Components
cytoplasm, immunological synapse, intracellular, membrane fraction, neuromuscular junction, nucleus, plasma membrane, sarcolemma, soluble fraction
Literature References
- 16252004Thuille N, Heit I, Fresser F, Krumböck N, Bauer B, Leuthaeusser S, Dammeier S, Graham C, Copeland TD, Shaw S, Baier G. Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes.EMBO J 2005 Nov 16;24(22):3869-80
- 14988727Li Y, Hu J, Vita R, Sun B, Tabata H, Altman A. SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway.EMBO J 2004 Mar 10;23(5):1112-22
- 10836144Sah VP, Seasholtz TM, Sagi SA, Brown JH. The role of Rho in G protein-coupled receptor signal transduction.Annu Rev Pharmacol Toxicol 2000;40:459-89 View 3825 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, diacylglycerol binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein kinase C activity, protein serine/threonine kinase activity, transferase activity, zinc ion binding
- Axonal Guidance Signaling
- Apoptosis Signaling
- fMLP Signaling in Neutrophils
- Thrombopoietin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- CCR5 Signaling in Macrophages
- CCR3 Signaling in Eosinophils
- Synaptic Long Term Depression
- GNRH Signaling
- Type II Diabetes Mellitus Signaling
- B Cell Receptor Signaling
- Corticotropin Releasing Hormone Signaling
- Aldosterone Signaling in Epithelial Cells
- CREB Signaling in Neurons
- IL-3 Signaling
- Role of NFAT in Regulation of the Immune Response
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Prolactin Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Thrombin Signaling
- Molecular Mechanisms of Cancer
- IL-8 Signaling
- Virus Entry via Endocytic Pathways
- IL-12 Signaling and Production in Macrophages
- G Beta Gamma Signaling
- VDR/RXR Activation
- Hepatic Cholestasis
- CD28 Signaling in T Helper Cells
- p70S6K Signaling
- Glioma Signaling
- 14-3-3-mediated Signaling
- Inositol Phosphate Metabolism
- iCOS-iCOSL Signaling in T Helper Cells
- Androgen Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Growth Hormone Signaling
- Huntington's Disease Signaling
- CXCR4 Signaling
- NF-κB Activation by Viruses
- Natural Killer Cell Signaling
- Synaptic Long Term Potentiation
- Leukocyte Extravasation Signaling
- Neuregulin Signaling
- Renin-Angiotensin Signaling
- Erythropoietin Signaling
- Endothelin-1 Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Mechanisms of Viral Exit from Host Cells
- HGF Signaling
- T Cell Receptor Signaling
- Nicotinate and Nicotinamide Metabolism
- Melatonin Signaling
- NRF2-mediated Oxidative Stress Response
- LPS-stimulated MAPK Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Xenobiotic Metabolism Signaling
- Macropinocytosis Signaling
- Fc Epsilon RI Signaling
- α-Adrenergic Signaling
- RAR Activation
- mTOR Signaling
- NF-κB Signaling
Protein Domains
Alcohol group acceptor phosphotransferase, C1 domain, C1A domain, C1B domain, C2 domain, kinase, kinase domain, protein binding, Protein kinase, protein kinase C, protein serine/threonine kinase, regulatory domain, V1 region
Subcellular Locations
cell periphery, cellular membrane, cytoplasm, cytoplasmic fraction, cytoskeleton, cytosol, cytosolic fraction, detergent-insoluble fractions, detergent-soluble fraction, immunological synapses, membrane rafts, microsomal fraction, nucleus, perinuclear region, plasma membrane, raft fractions
