POLD1 - polymerase (DNA directed), delta 1, catalytic subunit 125kDa
Entrez Gene Name: polymerase (DNA directed), delta 1, catalytic subunit 125kDa
Entrez GeneID: Human(5424)
, Mouse(18971), Rat(59294)
, Mouse(18971), Rat(59294) Synonyms: 125kDa, CDC2, DNA POLYMERASE DELTA, P125, POLD, POLD1
Gene Summary
- Human (5424): The DNA polymerase delta complex is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA; MIM 176740), the multisubunit replication factor C (see MIM 102579), and the 4 subunit polymerase complex: POLD1, POLD2 (MIM 600815), POLD3 (MIM 611415), and POLD4 (MIM 611525) (Liu and Warbrick, 2006 [PubMed 16934752]).[supplied by OMIM]
- Rat (59294): has DNA polymerase and 3'exonuclease activities; plays roles in DNA replication, base excision repair, and other types of DNA repair [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
base-excision repair, gap-filling, DNA replication, DNA replication proofreading, DNA synthesis during DNA repair, DNA-dependent DNA replication, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, nucleotide-excision repair, DNA gap filling, response to UV, S phase of mitotic cell cycle
Literature References
- 16510448Li H, Xie B, Zhou Y, Rahmeh A, Trusa S, Zhang S, Gao Y, Lee EY, Lee MY. Functional roles of p12, the fourth subunit of human DNA polymerase delta.J Biol Chem 2006 May 26;281(21):14748-55
- 14681455Hermjakob H, Montecchi-Palazzi L, Lewington C, Mudali S, Kerrien S, Orchard S, Vingron M, Roechert B, Roepstorff P, Valencia A, Margalit H, Armstrong J, Bairoch A, Cesareni G, Sherman D, Apweiler R. IntAct: an open source molecular interaction database.Nucleic Acids Res 2004 01 1;32(Database issue):D452-5
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68 View 254 categorized literature findings and their references in IPA
Molecular Functions
3'-5' exonuclease activity, chromatin binding, DNA binding, DNA-directed DNA polymerase activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding
Protein Domains
3'-5' exonuclease, chromatin binding, DNA binding, DNA-directed DNA polymerase, enzyme, Exonuclease domain, protein binding
