NFKB1 - nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Entrez Gene Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Entrez GeneID: Human(4790)
, Mouse(18033), Rat(81736)
, Mouse(18033), Rat(81736) Synonyms: DKFZp686C01211, EBP-1, KBF1, MGC54151, Nf kappa b DNA binding subunit, NF-KAPPAB, NF-KAPPAB1, NFKB, NFKB SUBUNIT P105/P50, NFKB-p105, NFKB1, NUCLEAR FACTOR KAPPA B DNA BINDING SUBUNIT, P105, p105 Nfkb, P50/P105
Gene Summary
- Human (4790): This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. [provided by RefSeq]
- Rat (81736): gene encodes a 105 kD protein that can be processed to create a 50 kD protein; the larger protein is a Rel protein-specific transcription inhibitor and the smaller protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
anti-apoptosis, apoptosis, inflammatory response, lymph node development, negative regulation of cellular protein metabolic process, negative regulation of cholesterol transport, negative regulation of cytokine production, negative regulation of interleukin-12 biosynthetic process, negative regulation of specific transcription from RNA polymerase II promoter, negative regulation of transcription, DNA-dependent, positive regulation of foam cell differentiation, positive regulation of lipid storage, positive regulation of specific transcription from RNA polymerase II promoter, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, regulation of transcription, DNA-dependent, response to copper ion, response to oxidative stress, signal transduction, transcription
Cellular Components
cytoplasm, cytosol, I-kappaB/NF-kappaB complex, nucleoplasm, nucleus, protein complex
Literature References
- 17510282Yang J, Liao X, Agarwal MK, Barnes L, Auron PE, Stark GR. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NF{kappa}B.Genes Dev 2007 Jun 01;21(11):1396-408
- 12486103Stehlik C, Fiorentino L, Dorfleutner A, Bruey JM, Ariza EM, Sagara J, Reed JC. The PAAD/PYRIN-Family Protein ASC Is a Dual Regulator of a Conserved Step in Nuclear Factor kappaB Activation Pathways.J Exp Med 2002 Dec 16;196(12):1605-1615
- 12208876Hinz M, Lemke P, Anagnostopoulos I, Hacker C, Krappmann D, Mathas S, Dörken B, Zenke M, Stein H, Scheidereit C. Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.J Exp Med 2002 Sep 2;196(5):605-17 View 16684 categorized literature findings and their references in IPA
Molecular Functions
actin binding, DNA binding, double-stranded DNA binding, heat shock protein binding, promoter binding, protein binding, protein dimerization activity, protein homodimerization activity, sequence-specific DNA binding, specific transcriptional repressor activity, transcription activator activity, transcription factor activity
- IL-15 Signaling
- Renin-Angiotensin Signaling
- Aryl Hydrocarbon Receptor Signaling
- April Mediated Signaling
- Type II Diabetes Mellitus Signaling
- Acute Myeloid Leukemia Signaling
- IL-10 Signaling
- IL-9 Signaling
- NF-κB Activation by Viruses
- Small Cell Lung Cancer Signaling
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- TREM1 Signaling
- Acute Phase Response Signaling
- BMP signaling pathway
- Prostate Cancer Signaling
- Xenobiotic Metabolism Signaling
- Gα12/13 Signaling
- PTEN Signaling
- Chronic Myeloid Leukemia Signaling
- IL-8 Signaling
- PPAR Signaling
- IL-6 Signaling
- Apoptosis Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- iCOS-iCOSL Signaling in T Helper Cells
- PI3K/AKT Signaling
- IL-17 Signaling
- Toll-like Receptor Signaling
- Thrombin Signaling
- B Cell Receptor Signaling
- CD40 Signaling
- G-Protein Coupled Receptor Signaling
- LPS-stimulated MAPK Signaling
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Tight Junction Signaling
- T Cell Receptor Signaling
- IL-15 Production
- Ceramide Signaling
- Role of NFAT in Regulation of the Immune Response
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PKR in Interferon Induction and Antiviral Response
- Androgen Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Type I Diabetes Mellitus Signaling
- PPARα/RXRα Activation
- IL-12 Signaling and Production in Macrophages
- RAR Activation
- Pancreatic Adenocarcinoma Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- GNRH Signaling
- NF-κB Signaling
- Erythropoietin Signaling
- fMLP Signaling in Neutrophils
- Hepatic Cholestasis
- Glucocorticoid Receptor Signaling
- LXR/RXR Activation
- HMGB1 Signaling
- 4-1BB Signaling in T Lymphocytes
- MIF Regulation of Innate Immunity
- CD28 Signaling in T Helper Cells
- Lymphotoxin β Receptor Signaling
- ILK Signaling
- CD27 Signaling in Lymphocytes
- Angiopoietin Signaling
- Dendritic Cell Maturation
- B Cell Activating Factor Signaling
- Induction of Apoptosis by HIV1
- Death Receptor Signaling
- Relaxin Signaling
- Molecular Mechanisms of Cancer
- Colorectal Cancer Metastasis Signaling
Protein Domains
actin binding, ankyrin repeat, death domain, dimerization domain, DNA binding, double-stranded DNA binding, IPT/TIG domain, nuclear localization sequence, protein binding, protein dimerization, protein homodimerization, Rel homology domain, signal response domain, specific transcriptional repressor, transcription factor, transcription regulator, transcriptional activator
Subcellular Locations
cytoplasm, cytoplasmic fraction, cytosol, cytosolic fraction, mitochondria, mitochondrial matrix, nuclear fraction, nuclear matrix, nucleus
