TLR1 - toll-like receptor 1
Entrez Gene Name: toll-like receptor 1
Entrez GeneID: Human(7096)
, Mouse(21897), Rat(305354)
, Mouse(21897), Rat(305354) Synonyms: CD281, DKFZp547I0610, DKFZp564I0682, KIAA0012, MGC104956, MGC126311, MGC126312, rsc786, TIL, TLR1, TOLL LIKE RECEPTOR 1
Gene Summary
- Human (7096): The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
activation of NF-kappaB-inducing kinase activity, defense response, defense response to bacterium, detection of triacylated bacterial lipoprotein, immune response, inflammatory response, innate immune response, macrophage activation, microglial cell activation during immune response, pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity, positive regulation of interleukin-6 biosynthetic process, positive regulation of tumor necrosis factor biosynthetic process, response to bacterial lipoprotein, signal transduction, toll-like receptor signaling pathway
Cellular Components
cytoplasmic vesicle, integral to membrane, integral to plasma membrane, intrinsic to membrane, membrane, phagocytic vesicle membrane, plasma membrane
Literature References
- 18469830Artis D. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut.Nat Rev Immunol 2008 Jun 01;8(6):411-20
- 18483500Cerutti A. The regulation of IgA class switching.Nat Rev Immunol 2008 Jun 01;8(6):421-34
- 17868652Unterholzner L, Bowie AG. The interplay between viruses and innate immune signaling: Recent insights and therapeutic opportunities.Biochem Pharmacol 2008 Feb 01;75(3):589-602 View 1118 categorized literature findings and their references in IPA
Molecular Functions
lipoprotein binding, protein binding, receptor activity, transmembrane receptor activity, triacylated lipoprotein binding
Protein Domains
extracellular domain, intracellular domain, leucine-rich repeat, lipoprotein binding, Toll/IL-1 receptor domain, transmembrane receptor, triacylated lipoprotein binding
